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Biology textbooks teach us that adult cell types remain fixed in the identity they have acquired upon differentiation. By inducing non-insulin-producing human pancreatic cells to modify their function to produce insulin in a sustainable way, researchers at the University of Geneva (UNIGE), Switzerland, show for the first time that the adaptive capacity of our cells […]
Researchers at the Vetmeduni Vienna and the Ludwig Boltzmann Institute for Cancer Research have identified a new therapeutic strategy for Acute Myeloid Leukemia (AML), the most common form of acute leukemia. They found that the activity of the mutated oncogenic protein C/EBPα is dependent on a functional epigenetic helper, the MLL1 histone methyltransferase complex. Laboratory […]
Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call “chromatin.” Chromatin not only protects our genetic material from damage, but also organizes the entire genome by regulating the expression of genes in three dimensions, unwinding them to be presented to the cell’s gene-expression machinery and […]
A new drug shows potential to halt cancer cells’ growth by stunting the cells’ biological clock. The findings from scientists at the USC Michelson Center for Convergent Bioscience and Nagoya University’s Institute of Transformative BioMolecules (ITbM) advance a burgeoning area of research: turning the body’s circadian rhythms against cancer. Their study, conducted on human kidney […]
When bacteria or viruses enter the body, proteins on their surfaces are recognized and processed to activate T cells, white blood cells with critical roles in fighting infections. During T-cell activation, a molecular complex known as the microtubule-organizing center (MTOC) moves to a central location on the surface of the T-cell. Microtubules have several important […]
Researchers from Karolinska Institutet in Sweden have identified a protein that determines the identity and invasive properties of breast cancer cells. The finding could lead to the development of new therapeutic and diagnostic strategies to target breast cancer invasion and metastasis. The study is published in the scientific journal Cancer Research. Cancer cell invasion of […]
Sleep disruptions are associated with many brain disorders, including anxiety, dementias, and traumatic brain injury. While these disruptions are sometimes viewed as a side effect of brain disorders, new findings presented today suggest that aberrant sleep-wake cycles can also drive brain pathology. The studies were presented at Neuroscience 2018, the annual meeting of the Society […]
Seneca Valley Virus sounds like the last bug you’d want to catch, but it could be the next breakthrough cancer therapy. Now, scientists at the Okinawa Institute of Science and Technology (OIST) and the University of Otago have described exactly how the virus interacts with tumors — and why it leaves healthy tissues alone. The […]
A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine. Scientists discovered the protein — called Dazl — controls a network of genes essential for developing sperm to replicate and survive. The findings, published in Cell Reports, could lay […]
Walter and Eliza Hall Institute researchers have uncovered new insights into how the normal controls on cell growth are lost in cancer cells, leading to rapid tumour expansion. The findings could help researchers predict how cancer cells respond to chemotherapy and improve our understanding of how cancer evolves. Published in the journal Cell Cycle, the […]