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The combination of copanlisib plus rituximab led to a 48% reduction in the risk of disease progression or death, when compared with rituximab plus placebo in a phase 3 trial of patients with relapsed, indolent non-Hodgkin lymphoma (NHL). The trial, dubbed CHRONOS-3, is the first to report “a broad benefit” across histologic subtypes of relapsed, indolent […]
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell "poor" to T cell […]
Researchers at the Francis Crick Institute, as part of an international collaboration of scientists through the Pan-Cancer Analysis of Whole Genomes Consortium, have analyzed the whole genomes of tumor samples from over 2,600 patients with different types of cancer. They identified a high prevalence of genetic diversity within individual tumors, which they further characterized. Their […]
On the surface, Parkinson's disease -; a neurodegenerative disorder -; and melanoma -; a type of skin cancer -; do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson's disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular link […]
People with ovarian cancer frequently receive aggressive end-of-life care despite industry guidelines that emphasize quality of life for those with advanced disease, according to a recent study. In fact, by 2016, ICU stays and emergency department visits in the last month of life had become more common for people with ovarian cancer than they were […]
Excessive intakes of saturated fat and added sugar are a leading cause of premature mortality among adults in the U.S., contributing to nearly 700,000 deaths each year, but nutritional research aimed at improving health is often challenging due to limitations in accurately tracking participants' food intake. A new University of Arizona Health Sciences-led study aims […]
Excessive intakes of saturated fat and added sugar are a leading cause of premature mortality among adults in the U.S., contributing to nearly 700,000 deaths each year, but nutritional research aimed at improving health is often challenging due to limitations in accurately tracking participants' food intake. A new University of Arizona Health Sciences-led study aims […]
A possible explanation for why many cancer drugs that kill tumor cells in mouse models won’t work in human trials has been found by researchers with The University of Texas Health Science Center at Houston (UTHealth) School of Biomedical Informatics and McGovern Medical School. The research was published today in Nature Communications. In the study, […]
A new research study leveraging a database from the largest equal access health system in the US, the Department of Veteran Affairs, offers insight into the outcome of specific treatment patterns for advanced bladder cancer patients. Lead author Dr. Stephen Williams of the University of Texas Medical Branch says it is one of the first […]
New research offers insight into why regular, long-term use of low-dose aspirin may reduce the risk of death from colon and rectal cancers. Resarchers found that aspirin prevents blood cells called platelets from producing an enzyme that allows them to clump together. Tumor cells can attach to these clumps and spread (metastasize) throughout the body. […]