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A targeted drug has shown promising activity against brain metastases resulting from kidney cancer, achieving a 50 percent response rate, and supporting further studies of the drug in this patient group whose poor prognosis has created a significant unmet need. The drug, cabozantinib, is a tyrosine kinase inhibitor that attacks several targets in cancer cells. […]
Festival drug-related deaths are a growing public health concern. At present, there is limited evidence highlighting drug trends and harm-reduction practices among Irish festival attendees. One of the main health concerns for this cohort relates to the risks associated with high volumes of drugs being consumed as well as the combinations of substances used together. […]
Clot-busting drugs are the main treatment for stroke, but they have often not been recommended for people who have an aneurysm in their brains that has not ruptured. An aneurysm is a bulge in the wall of a blood vessel in the brain. A new study finds that these aneurysms rarely burst after treatment with […]
Zeroing in on specific brain regions when studying drug and alcohol abuse simplifies research but may leave out important insights. In fact, the landscape of the entire brain reorganizes during withdrawal, potentially hindering communication between regions, according to new research in mice published in eNeuro. Kimbrough et al. administered psychostimulant drugs to mice (cocaine, methamphetamine, […]
Two new molecules that generate minute amounts of the gas hydrogen sulfide have been found to prevent skin from aging after being exposed to ultraviolet light found in sunlight. Sunburn is a major cause of premature aging in skin, and a primary risk factor for skin cancer, and other skin problems associated with aging. Now, […]
Researchers at UT Southwestern announced successful results of a clinical trial for a commonly prescribed weight-loss drug called liraglutide. In adults who are overweight or have obesity combined with high cardiovascular risk, once-daily liraglutide combined with lifestyle interventions significantly lowered two types of fat that have been associated with risk to heart health: visceral fat […]
A combination of the kinase-inhibitor drug cabozantinib and the immunotherapy drug nivolumab can make curative surgery possible in some liver cancer patients who would normally not be considered surgery candidates. Results published July 29 in the journal Nature Cancer by researchers at the Johns Hopkins Kimmel Cancer Center describe the benefits of this drug combination. […]
Early 2020 saw the world break into what has been described as a “war-like situation”: A pandemic, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the likes of which majority of the living generations across most of the planet have not ever seen. This pandemic has downed economies and resulted in hundreds of […]
A drug used to treat people living with Type 2 diabetes could also help improve their heart function, according to new research. An estimated 3.7 million people in the UK are diagnosed with the condition which can damage the walls of the arteries and lead to a heart attack or heart failure. Researchers at the […]
Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments. The machine learning algorithms developed by the Metabolomics and Metagenomics Lab match the signals of a microbe's metabolites with […]