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Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver, according to the peer-reviewed journal Human Gene Therapy. The study was done in a mouse model of […]
Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation. Proteolysis-targeting chimeras or PROTACs are a promising type of protein-degrader molecules, but their effectiveness has been challenged by their limited ability to accumulate inside cells. In this study published in the journal Nature Communications, a […]
Genome editing technology is helping A*STAR scientists unravel how the Influenza A virus (IAV) exploits human anti-viral responses. IAV remains a key challenge for global health resources, not least because of wide variations in symptom severity experienced by different people, even when they are infected by the same strain. This implies that there are host […]
Long before molly (MDMA) came on the scene, pot was considered the drug of choice to get in the mood for love. Now science is confirming what children of the ’60s have long known. Marijuana can make you more amorous more often. A research study in the Journal of Sexual Medicine (JSM) explored the connection […]