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An international study led by the University of Oulu’s researchers reports five new genetic loci predisposing to atopic dermatitis. Based on three extensive biobanks, the study helps to understand the pathogenic mechanisms behind the disease and may open up opportunities for developing new forms of treatment. Atopic dermatitis (atopic eczema) is an inflammatory skin disease […]
A team of researchers led by a biomedical scientist at the University of California, Riverside, has identified a novel mechanism by which loss-of-function mutations in the gene PTPN2, found in many patients with inflammatory bowel disease, or IBD, affect how intestinal epithelial cells maintain a barrier. The intestinal epithelium, a single layer of cells, plays […]
The EU’s General Data Protection Regulation (GDPR) has created a great deal of uncertainty about how key requirements should be interpreted. This means that collaborators in international genetic research projects do not always agree on fundamental issues such as whether they are processing personal data, consent requirements under the GDPR and on what basis genetic […]
Researchers at Karolinska Institutet, together with British colleagues, have conducted the largest study to date in search of genetic markers about cluster headache. In the long term, it can hopefully pave the way for more effective treatments. The study is published in the scientific journal Annals of Neurology. Cluster headache leads to extremely intense and […]
By including multi-ethnic participants, a largescale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans alone. The international MAGIC collaboration, made up of more than 400 global academics, conducted a genome-wide association meta-analysis led by the University of Exeter. Now […]
Liver disease, from metabolic and bacterial causes, is a growing concern. What connects these dots? The gut, or more specifically, bacteria in the gut. Bacteria that cause inflammation in the mouth are transported through the digestive tract to the gut and liver, where they can cause liver inflammation. Lipopolysaccharides, important structural molecules in some bacteria, […]
Genome-wide association studies (GWAS) have identified thousands of genetic variants that are associated with a wide range of diseases. But these studies often fall short of establishing what a genetic variant does to bring about a particular trait or disease. “The challenge has been that many of these variants are difficult to interpret,” said Jesse […]
Being persistently lonely during midlife (ages 45-64) appears to make people more likely to develop dementia and Alzheimer's Disease (AD) later in life. However, people who recover from loneliness, appear to be less likely to suffer from dementia, compared to people who have never felt lonely. Loneliness is a subjective feeling resulting from a perceived […]
A UCLA-led research team has identified a chemical cocktail that enables the production of large numbers of muscle stem cells, which can self-renew and give rise to all types of skeletal muscle cells. The advance could lead to the development of stem cell-based therapies for muscle loss or damage due to injury, age or disease. […]
TARM1 is a receptor protein whose role in the functioning of the immune system is unknown. In a new study, scientists from Japan have explored the potential role of TARM1 in the pathogenesis of rheumatoid arthritis by analyzing mouse models. They found that TARM1 activated dendritic cells, and development of collagen-induced arthritis (CIA) was notably […]