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Mitochondrial disorders affect around 1 in 4300 people and cause progressive, incurable diseases. They are amongst the most common inherited diseases but are difficult for clinicians to diagnose, not least because they can affect many different organs and resemble many other conditions. Current genetic testing regimes fail to diagnose around 40% of patients, with major […]
A twin study recently completed at the University of Helsinki indicates that the machinery responsible for energy handling in fat tissue is working poorly in obesity. In the study, a clear reduction was seen in the activity of mitochondrial genes in obesity in fat tissue, while similar genome-level change in muscle mitochondria was minor. A […]
In a recent report posted to the bioRxiv* preprint server, researchers from the United Kingdom and Uganda reveal unique protein features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to other representatives of Sarbecoviruses. The causative agent of the coronavirus disease 2019 (COVID-19), SARS-CoV-2, belongs to the Betacoronavirus genus and Sarbecovirus subgenus of the […]
The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown. Researchers from Brigham and Women's Hospital, Massachusetts General Hospital (MGH), and the Broad Institute […]
In a recent report made available on bioRxiv* preprint server, researchers from Poland and Finland reveal a spillover event of mink-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from farmed mink to humans after an extensive adaptation process. Study: Zoonotic spillover of SARS-CoV-2: mink-adapted virus in humans. Image Credit: An inspiration / Shutterstock Even before […]
Apoptosis is a form of programmed cell death, which occurs in cells that are irreparably damaged or in cells infected by some viruses. This mechanism is extremely important in limiting a virus’s replication and its spread to other neighboring cells. A new paper in the journal Life presents an early review of the viral factors […]
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has largely defied attempts to contain its spread by non-pharmaceutical interventions (NPIs). With the massive loss of life and economic damage, the only way out, in the absence of specific antiviral therapeutics, has been the development of […]
In late-December 2019, the coronavirus disease 2019 (COVID-19) was first detected in Wuhan City, China, causing an easily transmissible respiratory illness. By March 2020, the World Health Organization (WHO) declared its outbreak a global pandemic. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 has infected over 107.48 million people globally. To date, […]
Next generation sequencing (NGS), often referred to as massively parallel sequencing or deep sequencing, refers to a DNA sequencing technology that enables sequencing of millions of small DNA fragments in unison. This generates a massive pool of data and NGS has revolutionized genomic research studies. The data created can reach gigabytes in size (the equivalent […]
Alstrom syndrome has been the focus of attention, among other ciliopathies, in research on the biological functions of cilia as well as the best mode of treatment of these disorders. The ALMS1 gene has been associated with this condition. Physiological Roles of ALMS1 Protein The ALMS1 gene has been the locus of research because of […]