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Adding an immune checkpoint inhibitor to anti-HER2 treatment in breast cancer does not improve pathological complete response (pCR), according to the primary analysis of the IMpassion050 trial presented today during the ESMO Virtual Plenary. The phase III trial is the first to report data comparing a neoadjuvant anti-HER2 based regimen with or without the anti-PD-L1 […]
The cover for issue 55 of Oncotarget features Figure 3, “Romidepsin exhibits anti-tumor effect in xenograft model of DDLPS,” by Seligson, et al. Here the researchers present in silico, in vitro, and mouse xenograft studies that suggest that specifically targeting HDAC2 reduces MDM2 expression and has anti-tumor affects in DDLPS. In a murine DDLPS xenograft […]
Our brains do a remarkable job of encoding visual information about the world around us, providing an almost instantaneous report about rapidly changing conditions that is critical for guiding our behavior. Integral to the brain’s encoding mechanism is the presence of neurons that respond selectively to specific visual features, generating electrical activity that reliably signals […]