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Stress can impair memory, reduce brain size in middle age

Adults in their 40s and 50s with higher levels of cortisol — a hormone linked to stress — performed worse on memory and other cognitive tasks than peers of the same age with average cortisol levels, research found. Higher cortisol in the blood also was associated with smaller brain volumes, according to the study, published […]

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Recognizing the uniqueness of different individuals with schizophrenia: Research reveals large differences between individual patients

Schizophrenia is an extremely variable psychiatric disorder which is diagnosed based on the presence of specific symptoms. Thomas Wolfers and André Marquand of Radboud university medical center investigated how much the brains of individual patients diagnosed with schizophrenia differ from the ‘average’ patient. For this purpose, they compared brain scans of 250 healthy individuals with […]

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Effective ketamine doses for treatment-resistant depression

A study led by Massachusetts General Hospital (MGH) investigators identifies two subanesthetic dosage levels of the anesthetic drug ketamine that appear to provide significant symptom relief to patients with treatment-resistant depression. In the October 2018 issue of Molecular Psychiatry they describe finding that single intravenous doses of 0.5 mg/kg and 1.0 mg/kg were more effective […]

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Link between childhood adversity, burnout and depression

A study on childhood adversity at The University of Texas at El Paso School of Nursing found that undergraduate nursing students who were exposed to a higher number of adverse childhood experiences (ACEs) — such as abuse, neglect or family dysfunction — encountered higher levels of burnout and depression. ACEs can have negative, lasting effects […]

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Rethinking lethality in youth suicide attempts: Firearms are a major factor in first suicide attempts in youth ages 10 to 24

First suicide attempts are more lethal than previously realized, reports a study of children and adolescents published in the Journal of the American Academy of Child and Adolescent Psychiatry (JAACAP). Seventy-one percent of youth dying by suicide did so on their first attempt, also known as the “index” attempt; the authors also found that firearms […]

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Anxiety, depression, other mental distress may increase heart attack, stroke risk in adults over 45

Adults ages 45 or older who experience psychological distress such as depression and anxiety may have an increased risk of developing cardiovascular disease, according to new research in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. In a study of 221,677 participants from Australia, researchers found that: among women, high/very high psychological distress […]

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Maternal depression may alter stress and immune markers in children

New research suggests that depression in women may affect their children’s stress and physical well-being throughout life. For the Depression & Anxiety study, researchers followed 125 children from birth to 10 years. At 10 years, mothers’ and children’s cortisol (CT) and secretory immunoglobulin (s-IgA) — markers of stress and the immune system — were measured, […]