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New research shows that non-steroidal anti-inflammatory drugs (NSAIDs) reduced both antibody and inflammatory responses to SARS-CoV-2 infection in mice. The study appears this week in the Journal of Virology, a publication of the American Society for Microbiology. The research is important because “NSAIDs are arguably the most commonly used anti-inflammatory medications,” said principal investigator Craig […]
Using stem cells to regenerate parts of the skull, scientists corrected skull shape and reversed learning and memory deficits in young mice with craniosynostosis, a condition estimated to affect 1 in every 2,500 infants born in the United States, according to the Centers for Disease Control and Prevention. The only current therapy is complex surgery […]
Alzheimer’s disease is characterized by the presence of amyloid plaques in the patient’s brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain. Two CNRS scientists from the Coordination Chemistry Laboratory recently developed, with their colleagues from the Guangdong University of Technology and Shenzhen University (China), a molecule that […]
The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The researchers fed the compound to pregnant mice carrying […]
The University of Alabama at Birmingham and Southern Research have discovered a new drug candidate that offers a major advance in the treatment for diabetes. Tested on isolated human and mouse pancreatic islets, mouse and rat cell cultures and animal models of both Type 1 and Type 2 diabetes, the experimental drug significantly improved four […]
Emory researchers have found that adding good bacteria into the intestines can guide the development of the enteric nervous system, also called “the gut brain,” while increasing intestinal motility, or movement of the digestive tract, in a mouse model. The results are good news for medical conditions such as irritable bowel syndrome, Parkinson’s disease, autism […]
Giving mouse moms a supplement called nicotinamide riboside (NR) while they are nursing provides physical and behavioral benefits to both mothers and pups, according to a new study by researchers at the University of Iowa. Mother mice given the NR supplement lost weight faster and produced more milk than mothers not fed NR. In addition […]
There is an urgent need to develop a vaccine to prevent gonorrhea infection due to rapidly increasing incidence and growing antibiotic resistance. BUSM researchers (in collaboration with University of Toronto researchers) have been investigating the use of animal models of gonorrhea, to study how the infection evolves and for potential use to determine the efficacy […]
The MODEL-AD Center, an ambitious project to develop and distribute precise mouse models of late-onset Alzheimer’s disease (AD), has released eight new models carrying genetic mutations found in patients. In past decades, most AD researchers had to rely on mouse models that carried a genetic mutation associated with the relatively rare, early-onset, familial version of […]
Wrinkled skin and hair loss are hallmarks of aging. What if they could be reversed? Keshav Singh, Ph.D., and colleagues have done just that, in a mouse model developed at the University of Alabama at Birmingham. When a mutation leading to mitochondrial dysfunction is induced, the mouse develops wrinkled skin and extensive, visible hair loss […]