Health Problems

Testosterone Replacement Therapy for Men: Risks and Benefits

Skip to: What is Testosterone Replacement Therapy? What are the Benefits of TRT? What are the Risks of TRT? Testosterone plays a vital role in the human body. Its effects increase muscle and bone strength and density, induce hematopoiesis, and drive libido and sexual function. Testicular production of testosterone typically declines with age, which can […]

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Tumorsphere Formulation and Use in Cancer Stem Cell Research

Skip to: What are tumorspheres? Tumorsphere formation assay Technical notes on tumorsphere cultivation What are the types of cancer stem cell (CSC) tumorspheres? Tumorspheres for screening anti-CSC drugs What is the future of tumorspheres? What are tumorspheres? Numerous studies have pointed out that cancer stem cells (CSCs) play an important role in cancer progression, metastasis, […]

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Fragmenting ions and radiation sensitizers

A new study using mass spectrometry is helping piece together what happens when DNA that has been sensitized by the oncology drug 5-fluorouracil is subjected to the ionising radiation used in radiotherapy. The anti-cancer drug 5-fluorouracil (5FU) acts as a radiosensitizer: it is rapidly taken up into the DNA of cancer cells, making the cells […]

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Killing the seeds of cancer: A new finding shows potential in destroying cancer stem cells: The finding could provide an important step toward drugs that help prevent recurrent cancers

Scientists at The University of Toledo investigating improvements to a commonly used chemotherapy drug have discovered an entirely new class of cancer-killing agents that show promise in eradicating cancer stem cells. Their findings could prove to be a breakthrough in not only treating tumors, but ensuring cancer doesn’t return years later — giving peace of […]

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Molecular chatter makes for a ‘hot tumor’

A Ludwig Cancer Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells. “We show that two key chemokines, CCL5 and CXCL9, are universally implicated in T cell infiltration across all solid tumors,” said George […]