Health News

ChIP-seq Advantages and Limitations

ChIP-seq, or chromatin immunoprecipitation and sequencing, is a technique that allows researchers to understand transcriptional regulation via mapping of protein-DNA interactions and epigenetic markers on a genome-wide scale. ChIP-seq has several advantages over previous methods, such as ChIP-chip, but like all techniques, ChIP-seq has its limitations. urfin | Shutterstock ChIP-seq ChIP-seq was one of the […]

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MALDI Mass Spectrometry in Biomedicine

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry enables rapid profiling of various biomolecules from both tissues and biofluids. Rost9 | Shutterstock Although MALDI was originally used for the analysis of peptides and proteins, it now plays an important role in biomarker discovery, genotyping, identification of microorganisms, lipidomic analysis, and metabolomics. Improvements in the selection of […]

Health News

MALDI Mass Spectrometry in Biomedicine

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry enables rapid profiling of various biomolecules from both tissues and biofluids. Rost9 | Shutterstock Although MALDI was originally used for the analysis of peptides and proteins, it now plays an important role in biomarker discovery, genotyping, identification of microorganisms, lipidomic analysis, and metabolomics. Improvements in the selection of […]

Health News

A protein that can melt tumors

For the second time, cancer researchers at Vanderbilt have discovered a protein that—when genetically manipulated to impede it from interacting with a gene responsible for cancer genesis—effectively melts tumors in days. The article, “MYC regulates ribosome biogenesis and mitochondrial gene expression programs through interaction with Host Cell Factor-1,” was published in the journal eLife on […]

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Elusive link between seizures, cell signaling protein ID’d in zebrafish

For the brain to learn, retain memories, process sensory information, and coordinate body movements, its groups of nerve cells must generate coordinated electrical signals. Disorder in synchronous firing can impair these processes and, in extreme cases, lead to seizures and epilepsy. Synchrony between neighboring neurons depends on the protein connexin 36, an essential element of […]

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New insights on a common protein could lead to novel cancer treatments

A new University of Colorado Boulder-led study sheds light on a protein key to controlling how cells grow, proliferate and function and long implicated in tumor development. The findings, published this week in the journal Genes and Development, could lead not only to new therapies for hard-to-treat cancers, but also inform novel treatments for neurological […]