Is Evolution of the Human Brain to Blame for Some Mental Disorders?

THURSDAY, Aug. 9, 2018 — Evolutionary changes in the human brain may be responsible for psychiatric illnesses such as schizophrenia and bipolar disorder, new research suggests.

The researchers identified long, noncoding stretches of DNA (called “repeat arrays”) in a gene that governs calcium transport in the brain. Their findings were published Aug. 9 in the American Journal of Human Genetics.

“Changes in the structure and sequence of these nucleotide arrays likely contributed to changes in CACNA1C function during human evolution and may modulate neuropsychiatric disease risk in modern human populations,” senior author David Kingsley said in a journal news release. Kingsley is a professor of developmental biology at Stanford University in California.

The study authors suggested that the findings could lead to improved treatment for patients with schizophrenia and bipolar disorder, which affect about 3 percent of people worldwide.

Classifying patients based on their repeat arrays may help identify those most likely to respond to current calcium channel drugs, which so far have produced mixed results, Kingsley said.

He added that more research is needed to determine whether patients with a genetic variation of CACNA1C have too much or too little calcium channel activity.

The repeat arrays in the CACNA1C gene occur only in humans. Kingsley said that suggests the arrays may have given humans an evolutionary advantage, even if they increased the risk of conditions such as schizophrenia and bipolar disorder.

More information

The U.S. National Institute of Mental Health has more on schizophrenia.

Posted: August 2018

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Tess Holliday’s Son Hopped in Her Bathtub While She Was Trying to Get Some Self-Care Time—and Her Reaction Is Priceless

Tess Holliday has earned lots of fans as a model and body positive activist who speaks her mind when it comes to beauty standards and body peace. But she’s also a mom, and she’s just as unfiltered when she comments on the joy and chaos of motherhood.

Her latest so-relatable share is her new Instagram post. Holliday wrote that she was trying to score a little me time by taking a bath…when her 2-year-old son, Bowie, decided to join in. 

“When you have meetings & filming at your house all day, & decide to take a nice, relaxing bath before the chaos starts… but then your toddler sees you trying to sneak into the bathroom & screams until you let him take a bath with you,” she captioning a black-and-white photo of the mother-son duo.

When you have meetings & filming at your house all day, & decide to take a nice, relaxing bath before the chaos starts… but then your toddler sees you trying to sneak into the bathroom & screams until you let him take a bath with you. Normally it wouldn’t be an issue, but I have a tattoo on my leg that can’t get wet- but hey, I might be fat, but I’m flexible AF. 😈😛(Also he screamed for 5 mins after this was taken because I wouldn’t let him play with the razor you see him grabbing 🤷🏻‍♀️) This photo isn’t “flattering”, but I don’t care. I’m proud of my body, & what it’s capable of & how funny & ridiculous my life/motherhood is. ✌🏻 #thisismotherhood #effyourbeautystandards

A post shared by T E S S 🔥 (@tessholliday) on

To make room in the tub for Bowie, Holliday had to put in some additional legwork. She has a tattoo on her leg that can’t get wet, and the photo shows her lifted right leg and toes clutching the shower niche. (“Hey, I might be fat, but I’m flexible AF,” she wrote.) 

As she continued to make light of her disrupted R&R session, Holliday got real about the not-so-tranquil time spent with her little one. While the two seem fairly relaxed in the photo, she was sure to set the record straight.

“Also he screamed for 5 mins after this was taken because I wouldn’t let him play with the razor you see him grabbing,” she said.

And no Tess Holliday post would be complete without a message about self-love and having a positive body image. The founder of the platform @effyourbeautystandards ended her Instagram with a note about her body.

“This photo isn’t ‘flattering’, but I don’t care,” she wrote. “I’m proud of my body, & what it’s capable of & how funny & ridiculous my life/motherhood is.”

Holliday has provided us with a space to see what motherhood really looks like. While so many are wondering how influencers keep up their “perfect” lives, Holliday’s unedited stories and photos remind us to accept and enjoy the chaos.

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9 Things Some Men Are Too Afraid to Ask For in Bed

No matter how much crazy-great sex you and your partner might be having, admit it: You’ve wondered if there’s any desire he’s holding back. Hey, chances are you have a fantasy or curiosity that you may or may not have worked up the courage to divulge just yet, so what’s his?

To find out, we asked some men what they’re not asking for in the bedroom (but secretly kind of want to). Their answers may or may not surprise you, but regardless, it’s a good reminder that we can all be a little more open behind closed doors.

 

“Dominate me! Having to ask kind of defeats the purpose.” —Dean, 27

“Group sex is something I think would be a crazy experience, but there’s never been a partner who I would ask for that. It would take a lot of alcohol to admit.” —Daniel, 24

“I wish I could just ask for a blowjob sometimes without feeling like I’m asking to be serviced.” —Andrei, 26

“I like it when women are aggressive and creative [and] take initiative and surprise me. You can imagine that it could be difficult to ask your partner to be more spontaneous though.” —Zaiden, 29

“I’ve always wanted to tie a girl up, but I’m worried about asking for that. I watch Law & Order. I know how wrong that can go.” —Bill, 21 

“I love it when a girl talks dirty, but I would be embarrassed to ask her to do it. I wouldn’t want her to ask me to do it back. I don’t know how!” —Tommy, 26

“Threesomes. I wouldn’t want to hurt her feelings and have her interpret it like, ‘Oh, you don’t like me? You need more?'” —Grant, 25

“What I’ve always wanted to do is have sex with a girl between her boobs, but I wouldn’t want to ask. It could be degrading.” —Billy, 27

There are probably things you’re a little too shy to ask for in bed too, so hopefully this can serve as inspiration to open up your bedroom dialogue and remind each other that if you don’t ask, you’ll never know the answer. Whether there’s something you want to try or you just want to gauge your partner’s fantasies, start by having an open, honest, and judgment-free conversation about it. Of course, this doesn’t mean you have to check everything off each person’s list (if it’s not your thing, it’s not your thing), but simply sharing your desires and telling them what you want can go a long way toward an amazing sex life.

This article originally appeared on Women’s Health.

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