Health News

A new molecular player involved in T cell activation

When bacteria or viruses enter the body, proteins on their surfaces are recognized and processed to activate T cells, white blood cells with critical roles in fighting infections. During T-cell activation, a molecular complex known as the microtubule-organizing center (MTOC) moves to a central location on the surface of the T-cell. Microtubules have several important […]

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A Trojan horse delivery method for miRNA-enriched extracellular vesicles

A method for large-scale production of extracellular vesicles enriched with specific microRNAs (miRNAs) has been developed in the Wake Forest Institute for Regenerative Medicine (WFIRM) labs, offering a manufacturing standardization process which may have therapeutic applications and clinical impact. Extracellular vesicles are currently of particular interest in the scientific community for their therapeutic potential as […]

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Single protein controls thousands of genes essential for sperm development: New regulatory mechanism could underlie male infertility

A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine. Scientists discovered the protein — called Dazl — controls a network of genes essential for developing sperm to replicate and survive. The findings, published in Cell Reports, could lay […]

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New platform based on biology and nanotechnology carries mRNA directly to target cells: Combined platform provides safe, effective passage for therapies treating cancer and other diseases, researchers say

Delivering an effective therapeutic payload to specific target cells with few adverse effects is considered by many to be the holy grail of medical research. A new Tel Aviv University study explores a biological approach to directing nanocarriers loaded with protein “game changers” to specific cells. The groundbreaking method may prove useful in treating myriad […]

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Imaging collaboration sheds new light on cancer growth

Walter and Eliza Hall Institute researchers have uncovered new insights into how the normal controls on cell growth are lost in cancer cells, leading to rapid tumour expansion. The findings could help researchers predict how cancer cells respond to chemotherapy and improve our understanding of how cancer evolves. Published in the journal Cell Cycle, the […]

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How fatal biofilms form

By severely curtailing the effects of antibiotics, the formation of organized communities of bacterial cells known as biofilms can be deadly during surgeries and in urinary tract infections. Yale researchers have just come a lot closer to understanding how these biofilms develop, and potentially how to stop them. Biofilms form when bacterial cells gather and […]

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Strategies to protect bone health in hematologic stem cell transplant recipients

Hematopoietic stem cell transplantation (HSCT) is the treatment of choice for many patients with malignant and non-malignant hematological diseases, such as leukemia and multiple myeloma. The success of recent advances in such transplantation techniques and supportive care measures, has led to greater numbers of long-term HSCT survivors. Consequently, an increasing patient population is impacted by […]

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Heart attack: Substitute muscle thanks to stem cells

Myocardial infarction — commonly known as a heart attack — is still one of the main causes of death. According to the Federal Statistical Office, more than 49,00 people died of its consequences. And yet the mortality after heart attack has greatly decreased over the past decades: As compared to the early 1990s, it has […]

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Misfolded proteins serve as ‘inherited memory’ of toxic insults

Protein aggregates have a bad reputation in conditions such as Alzheimer’s disease and Parkinson’s disease, but in bacteria, inheritance of aggregates by daughter cells may help protect against the same toxic stresses that triggered them in parental cells, according to a new study publishing 28 August in the open access journal PLOS Biology, by Sander […]