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(HealthDay)—For patients with refractory or relapsed peripheral T-cell lymphoma (R/R-PTCL), three- and five-year overall survival (OS) and progression-free survival (PFS) are similar with allogeneic or autologous hematopoietic stem cell transplant (HSCT), but transplant-related mortality (TRM) is higher with allogeneic HSCT, according to a review published online May 27 in JAMA Network Open. Jun Du, M.D., […]
UC San Francisco scientists have discovered a new way to control the immune system’s ‘natural killer’ (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection. The findings could also be used to enhance the ability of cancer immunotherapies to detect and destroy lurking tumors. The study, […]
Using stem cells to regenerate parts of the skull, scientists corrected skull shape and reversed learning and memory deficits in young mice with craniosynostosis, a condition estimated to affect 1 in every 2,500 infants born in the United States, according to the Centers for Disease Control and Prevention. The only current therapy is complex surgery […]
The older we get the more our brains will find it difficult to learn and remember new things. The research group led by Professor Federico Calegari used a method to stimulate the small pool of neural stem cells that reside in the brain in order to increase their number and the number of neurons generated […]
A Cornell study provides important new insights into a common and deadly type of gastric cancer. Incidence of this cancer, called gastric squamous-columnar junction (SCJ) cancer, also known as gastroesophageal cancer, rose 2.5 times in the United States between the 1970s and 2000s, while cases of all gastric cancers have decreased by more than 80% […]
Peter Mac scientists have found a way to target acute myeloid leukemia (AML) at its source—a discovery that could yield a more effective treatment for this aggressive and often incurable blood cancer. Prof Mark Dawson and Dr. Laura MacPherson led the international research team, in collaboration with researchers in Europe and Australia including at the […]
Psoriasis is not a congenital disorder—it only occurs later on in life and has various causes, such as stress or UV irradiation, some of which have not yet been explored. In biomedical science, this frequently occurring inflammatory skin disease is usually associated with a disorder in the immune system, in which the body’s immune response […]
Does the treatment success of a certain procedure depend on the number of cases in a hospital or on how often the doctors working there have already performed this procedure? In Germany, this is the subject of 8 commissions on minimum volumes awarded by the Federal Joint Committee (G-BA) to the Institute for Quality and […]
A research team at the University of California, Riverside, has found that electronic cigarettes, often targeted to youth and pregnant women, produce a stress response in neural stem cells, which are critical cells in the brain. Present throughout life, stem cells become specialized cells with more specific functions, such as brain cells, blood cells, or […]
A discovery of how stem cells are protected from viruses could inform the development of therapies for use in medicine, research suggests. The finding could help research aimed at boosting the immune response of stem cells—early stage cells with the potential to become specialised tissues—for use in treating disease or damaged tissues. The research identified […]