The researchers used the most advanced genomic and proteomic technologies available to tease out their proteogenomic characteristics, defined as genetic makeup (genomics), chemical modifications to DNA (epigenomics), messenger RNA located in cells that serves as template to make proteins (transcriptomics), and proteins (proteomics) and their modification by phosphate group (phosphoproteomics), a modification known to regulate […]
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Data sharing uncovers five new risk genes for Alzheimer’s disease
Analysis of genetic data from more than 94,000 individuals has revealed five new risk genes for Alzheimer’s disease, and confirmed 20 known others. An international team of researchers also reports for the first time that mutations in genes specific to tau, a hallmark protein of Alzheimer’s disease, may play an earlier role in the development […]
Study uncovers why heart attack triggers arrhythmia in some, explores potential treatment
A team of researchers led by the University of California San Diego has identified a genetic pathway that causes some individuals to develop an abnormal heart rhythm, or arrhythmia, after experiencing a heart attack. They have also identified a drug candidate that can block this pathway. The team reported their findings in a study published […]
Research uncovers key differences in brains of women and men with schizophrenia
Researchers from the Icahn School of Medicine at Mount Sinai have found clear disparities in the way males and females—both those with schizophrenia and those who are healthy—discern the mental states of others. The research, the first of its kind, will be published online on October 30, in Social Neuroscience. The research team examined emotional […]