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Disease X: Scientist says next pandemic is a matter of 'WHEN not if'

Next pandemic is a matter of ‘WHEN not if’: Scientist warns new ‘Disease X’ outbreak could be ‘around corner’ and warns global response must be ready

  • Mark Woolhouse says it is difficult to tell when such a disease may emerge
  • Edinburgh-based expert says mechanism of how it comes out is unpredictable
  • He and colleagues got WHO to add ‘Disease X’ to its priority diseases list in 2017
  • Scientists discover one or two viruses transmissible to humans every year or two

A leading British scientist has suggested another pandemic-causing ‘Disease X’ could be around the corner – and it is a matter of ‘when, not if’.

Professor Mark Woolhouse added that it is difficult to tell when such a disease may emerge, and the precise mechanism of how it comes out is always unpredictable.

The expert in infectious disease epidemiology at the University of Edinburgh said that pandemic flu is at the top of the list for outbreaks to be concerned about, but he added that there is a whole range of other viruses to be aware of. 

Mr Woolhouse told how he and some colleagues got the World Health Organisation to add something called Disease X to its list of priority diseases four years ago.

He said: ‘We thought that the next emerging pandemic might be a virus that we don’t even know about yet – quite frankly we thought it was the most likely scenario.’

Professor Mark Woolhouse, an expert in infectious disease epidemiology at the University of Edinburgh, has suggested another pandemic-causing ‘Disease X’ could be around the corner

Mr Woolhouse said he and some colleagues got the World Health Organisation (whose offices in Geneva are pictured) to add something called Disease X to its list of priority diseases in 2017

Mr Woolhouse added that in a meeting the following year experts considered what the disease might be, and one possibility they came up with was a novel coronavirus related to Mers or Sars.

He said: ‘I mean, it really couldn’t be more accurate than that. This new virus is so closely related to Sars, so they absolutely pinpointed it as one of the threats.’

What is Disease X? 

The World Health Organization says ‘Disease X’ represents the knowledge that a serious international epidemic could be caused by a pathogen which is unknown to cause human disease.

It is on a list of WHO priority diseases which are being studied by its research and development teams, along with:

  • Covid-19
  • Crimean-Congo haemorrhagic fever
  • Ebola virus disease and Marburg virus disease
  • Lassa fever
  • Middle East respiratory syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS)
  • Nipah and henipaviral diseases
  • Rift Valley fever
  • Zika

Asked if the next Disease X could potentially be around the corner, Prof Woolhouse said ‘absolutely’.

Speaking independently, he said: ‘You could use the phrase ‘it is when, not if’.

‘We can’t put a handle on when, of course. The precise mechanism by which a virus comes out is always extremely unpredictable. You can never predict precise events, so you have to do it on sort of statistical grounds probability.’

Mr Woolhouse said that every year or two scientists are discovering maybe one or two viruses that are transmissible to humans, and the rate has been constant for more than 50 years.

He added: ‘That’s going to keep happening. It’s picking up the ones that are actually going to cause the next pandemic out of this constant trickle of new viruses that’s coming along.

‘Occasionally one comes along, so spotting the rare event is always hard.’

Asked if there was now a greater appetite among policy makers to be aware of the risk of future pandemics, Mr Woolhouse said: ‘I’m not sure that there’s a lot of thinking going on about the next threat, while the world is concentrating full tilt on dealing with the one it’s got.

‘I absolutely agree that there needs to be more thought about that.’

He added that it was not that the UK did not have any plans, and actually had ‘pretty mature and sophisticated plans’ to react to the next pandemic influenza.

‘Unfortunately, I like to put it, we did a lot of work, we did our revision, we went into the exam room, and they gave us the wrong paper. 

Doctors tend to a patient in intensive care at Whiston Hospital in Merseyside last month

 

‘We were all prepared to meet the pandemic flu, and we got something else.

‘And that I think for me is the big lesson – I have tried to push this for many years now – is don’t be overly prescriptive about what you think’s going to come next.

‘Be broad-minded, open-minded about and look at the range of possibilities.

‘We absolutely do need to be more aware of these events, but I think this game of trying to guess what it will be is very risky.

‘We just played it, and it didn’t do us any favours. We prepared, as I say, for the wrong exam, and we don’t want to do that next time.’

The comments come as this week marks a year since the first coronavirus cases were reported in the UK, and the anniversary of the first known death in the country.

This Saturday also marks one year since the WHO declared a Public Health Emergency of International Concern (PHEIC) over Covid-19.

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