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By Shelley Farrar, MSc, BSc Cryo-electron microscopy, also known as Cryo-EM, is a technique for visualizing macromolecular structures which has been developed over the last two decades. It is a form of transmission electron microscopy which permits samples to be studied at cryogenic temperatures. Biological structures such as ribosomes and mitochondria from pathogens, ion channels […]
ChIP-seq, or chromatin immunoprecipitation and sequencing, is a technique that allows researchers to understand transcriptional regulation via mapping of protein-DNA interactions and epigenetic markers on a genome-wide scale. ChIP-seq has several advantages over previous methods, such as ChIP-chip, but like all techniques, ChIP-seq has its limitations. urfin | Shutterstock ChIP-seq ChIP-seq was one of the […]
In both ethical and scientific respects, Roma population groups are treated inappropriately in DNA databases and in genetic studies—potentially with consequences for investigations that draw on forensic genetic databases: this was the conclusion of Prof. Dr. Veronika Lipphardt and her colleague Dr. Mihai Surdu from the Chair of Science and Technology Studies at the University […]
It’s a fact of life that things break down. And when they do, whether it’s your car, the roof, or a blocked artery, there are people who we can call to help with the repairs. A lesser known fact of life is that DNA also regularly breaks down and needs to be repaired. Researchers led […]
Scientists at The Wistar Institute have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein. A rapidly reemerging tick-borne disease, POWV has been reported to be fatal in 10% of infected people with detrimental neurological consequences including encephalitis and meningitis. This new POWV vaccine candidate, […]
Systemic sclerosis is an autoimmune disorder that is characterized by excess deposition of connective tissue in the skin, lungs, kidneys and vessels, resulting in lung, heart and kidney dysfunction. In a new study, researchers from the University of Tsukuba revealed that patients with long stretches of repeat DNA sequences, also called microsatellite repeat polymorphism, in […]
An analysis of genetic studies covering 266,000 women has revealed 32 new sites on the human genome where variations in DNA appear to alter the risks of getting breast cancer. The study lead and senior authors included researchers at Johns Hopkins Bloomberg School of Public Health. The findings are thought to be the first to […]
A group led by researchers at Baylor College of Medicine has identified significant differences at the epigenetic level—the chemical tags in DNA that help regulate gene expression—between two clinically distinct forms of acute childhood malnutrition known as edematous severe acute malnutrition (ESAM) and non-edematous SAM (NESAM). The researchers report in the journal Nature Communications that […]
New insights into the journey from health to disease in the human liver have been made by scientists at the Wellcome Sanger Institute, Cancer Research UK Cambridge Institute, the University of Cambridge and their collaborators. In the largest study of its kind, the team documented in unprecedented detail how the accumulation of changes in our […]
Risk-free mouth-swab DNA test reveals if surgery patients are at risk of scarring badly after an operation First-of-its-kind screening takes less than a minute and is completely risk-free The simple, first-of-its-kind mouth-swab DNA test takes less than a minute After a week results can indicate the chances of an abnormal scar developing Surgery patients can […]