Health Problems

Unique brain ‘fingerprint’ can predict drug effectiveness

Personalized medicine—delivering therapies specially tailored to a patient’s unique physiology—has been a goal of researchers and doctors for a long time. New research provides a way of delivering personalized treatments to patients with neurological disease. Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University and the Ludmer Centre for Neuroinformatics and […]

Health Problems

Complexity of NMDA receptor drug discovery target revealed

Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression. NMDA receptors, critical for learning and memory, are sensors in the brain. Studying them in molecular detail is challenging, because they usually come in four parts, and the parts aren’t all the same. Researchers at […]

Health Problems

Novel drug therapy partially restores hearing in mice

A small-molecule drug is the first to preserve hearing in a mouse model of an inherited form of progressive human deafness, report investigators at the University of Iowa, Iowa City, and the National Institutes of Health’s National Institute on Deafness and Other Communication Disorders (NIDCD). The study, which appears online in Cell, sheds light on […]

Health Problems

Progress toward improved Wilson’s disease drug

Researchers at Cold Spring Harbor Laboratory (CSHL), working in collaboration with DepYmed Inc., a CSHL spinout company, today report that they have conducted promising preclinical experiments on a compound that could be used to treat Wilson’s disease and possibly other disorders—including certain types of cancer—in which levels of copper in the body are elevated, causing […]