Health News

Abnormal expression of genes in psychopathy

The expression of many genes that have previously been associated with autism is abnormal also in violent psychopathy, a new study shows. The researchers used stem cell technology to analyse the expression of genes and proteins in the brain cells of psychopathic violent offenders. Published in Molecular Psychiatry, the findings may open up new avenues […]

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Pluripotency: ‘Butterfly effect’ discovered: Single change at telomeres controls the ability of cells to generate a complete organism

Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants. But pluripotency is still a black box for science, controlled by unknown genetic (expression of genes) and epigenetic signals (biochemical marks that control […]

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Molecular biophysics: The ABC of ribosome recycling

Ribosomes, the essential machinery used for protein synthesis is recycled after each one round of translation. An enzyme called ABCE1 is responsible for this process and turns out to be remarkably plastic as Ludwig-Maximilians-Universitaet (LMU) in Munich biophysicists report. Ribosomes translate the genetic information, which is first transcribed into messenger RNAs by polymerases, into the […]

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New gene editor harnesses jumping genes for precise DNA integration

A new discovery by researchers at Columbia University Vagelos College of Physicians and Surgeons could fix one of the major shortcomings of current gene-editing tools, including CRISPR, and offer a powerful new approach for genetic engineering and gene therapy. Their new technology, called INTEGRATE, harnesses bacterial jumping genes to reliably insert any DNA sequence into […]

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Scientists uncover binding secret behind protein ‘superglue’: Mechanism found in Chinese herb helps to create lab-grown enzymes that may speed up drug development

Scientists from Nanyang Technological University, Singapore (NTU Singapore) have pinpointed how a special class of plant-derived enzymes, known as peptide ligases, work to join proteins together. Such binding is an important process in the development of drugs, for example in specifically attaching a chemotherapy drug to an antibody that recognises tumour markers to target cancer […]

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New ways to generate stem cells more efficiently

Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new and promising possibilities in precision medicine. To create them requires transforming a cell of one type, such as skin, into something of a blank slate, so it has the potential to become virtually any other kind of […]

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Large multi-ethnic genome-wide association study of asthma identifies novel associations

A large, multi-ethnic genome-wide association study (GWAS) of asthma identified novel associations with potential relevance for asthma susceptibility in older adults of diverse racial backgrounds. The study, “Large-scale, multi-ethnic genome wide association study identifies novel loci contributing to asthma susceptibility in adults,” appears in the April issue of the Journal of Allergy and Clinical Immunology. […]