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A single protein regulates a battery of key genes inside developing sperm, according to a new study out of Case Western Reserve University School of Medicine. Scientists discovered the protein — called Dazl — controls a network of genes essential for developing sperm to replicate and survive. The findings, published in Cell Reports, could lay […]
A reader recently asked me to explain what’s meant by overdiagnosis. I wasn’t surprised because it (and overtreatment) is the buzz word of the moment in medical circles. For the avoidance of doubt here’s the definition of overdiagnosis. It’s the diagnosis of a condition that, if unrecognised, wouldn’t cause symptoms or harm a patient. The […]
Think of it as a cancer therapy zag instead of a zig. While many groups are developing cancer therapies to target proteins and pathways that are highly active in cancer cells, a team of investigators from Brigham and Women’s Hospital and Boston Children’s Hospital, with collaborators at Memorial Sloan Kettering Cancer Center, is taking a […]
Myocardial infarction — commonly known as a heart attack — is still one of the main causes of death. According to the Federal Statistical Office, more than 49,00 people died of its consequences. And yet the mortality after heart attack has greatly decreased over the past decades: As compared to the early 1990s, it has […]
Japanese researchers have revealed for the first time that a specific protein plays a critical role in the development and metastasis of highly aggressive prostate and breast cancer cells. The study reports that large amounts of the fatty acid-binding protein 5 (FABP5), a kind of transport protein for fatty acids, promotes processes associated with cancer […]
Previous research has revealed that patients with acute myeloid leukemia who also have a particular mutation in a gene called NPM1 have a higher rate of remission with chemotherapy. About one-third of leukemia patients possess this favorable mutation, but until now, how it helps improve outcomes has remained unknown. Scientists from the University of Illinois […]