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Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver, according to the peer-reviewed journal Human Gene Therapy. The study was done in a mouse model of […]
A new review of data from 12 spaceflight experiments and simulated microgravity studies has shown that microgravity does not have a negative effect on stem-like cell-dependent tissue regeneration in newts, but in some tissues regeneration is faster and more robust. This valuable in vivo data has implications for understanding and managing the ability for repair […]
A contentious debate among diabetes researchers has surrounded the regeneration of pancreatic insulin-producing cells: not if these cells regenerate, but rather how. The long-held view that the islets of Langerhans can be replenished from pancreatic stem cells (progenitors) was replaced over the last decade by the notion that islets self-duplicate from existing cells. Now, in […]
Researchers have made a significant new discovery concerning the signaling mechanisms that enable newts to regrow their tails after injury. Specifically, this process is shown to require the coordinated activation of the Hedgehog (Hh) and Wnt pathways. The study is published in Stem Cells and Development. Mary G. Garry, Daniel J. Garry, and colleagues from […]