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A new study led by Hans-Martin Jäck of the Friedrich-Alexander University Erlangen-Nuremberg in Germany engineered clusters of neutralizing monoclonal antibodies using a transgenic mouse model. A unique characteristic for the antibodies was the different ways it bound to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the overall reduction in the viral spread for […]
Scientists have developed a new biomaterial that regrows blood vessels and bone, potentially providing a single-stage approach when repairing large bone defects. The study, led by researchers from RCSI University of Medicine and Health Sciences and SFI AMBER Centre, is published in the Journal of Controlled Release. Previous RCSI-led research had found that activating a […]
Elevated blood pressure, high cholesterol and diabetes increase the risk of heart disease. But a large study today reveals that in people with these conditions, increasing activity levels is associated with a reduced likelihood of heart events and mortality. The research is presented at ESC Preventive Cardiology 2021, an online scientific congress of the European […]
The combination of a 2-Photon 3D-printer with an innovative hydrogel-based bioink allows the direct printing of 3D structures containing living cells at both the meso- and microscale. Developed by UpNano GmbH (Vienna, Austria), the NanoOne Bio is a printer based on the successful NanoOne range of laser-powered 2-Photon 3D-printers that are able to build structures […]
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell "poor" to T cell […]
A twin study recently completed at the University of Helsinki indicates that the machinery responsible for energy handling in fat tissue is working poorly in obesity. In the study, a clear reduction was seen in the activity of mitochondrial genes in obesity in fat tissue, while similar genome-level change in muscle mitochondria was minor. A […]
A team led by scientists at the UNC School of Medicine identified a molecule called microRNA-29 as a powerful controller of brain maturation in mammals. Deleting microRNA-29 in mice caused problems very similar to those seen in autism, epilepsy, and other neurodevelopmental conditions. The results, published in Cell Reports, illuminate an important process in the […]
On the surface, Parkinson's disease -; a neurodegenerative disorder -; and melanoma -; a type of skin cancer -; do not appear to have much in common. However, for nearly 50 years, doctors have recognized that Parkinson's disease patients are more likely to develop melanoma than the general population. Now, scientists report a molecular link […]
Excessive intakes of saturated fat and added sugar are a leading cause of premature mortality among adults in the U.S., contributing to nearly 700,000 deaths each year, but nutritional research aimed at improving health is often challenging due to limitations in accurately tracking participants' food intake. A new University of Arizona Health Sciences-led study aims […]
Excessive intakes of saturated fat and added sugar are a leading cause of premature mortality among adults in the U.S., contributing to nearly 700,000 deaths each year, but nutritional research aimed at improving health is often challenging due to limitations in accurately tracking participants' food intake. A new University of Arizona Health Sciences-led study aims […]