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The mysterious, poliolike disease that has struck 414 people—mostly young children—across the United States since 2014 comes at a time when the public health system already is overstretched. Reported in 39 states and Washington, D.C., acute flaccid myelitis, known as AFM, causes muscle weakness and in some cases paralysis in the arms or legs, terrifying […]
The brain creates a map of our environment, which enables reliable spatial navigation. The Nobel Prize was awarded in 2014 for research into how this navigation system works at the cellular level. Researchers at the Medical Center – University of Freiburg, Ruhr-Universität Bochum, and the Chinese Academy of Sciences in Beijing have now shown that […]
The central nervous system of older individuals responds to movement and initiates muscular contraction differently compared to young individuals. This is the result of a study led by researcher Simon Walker at the University of Jyväskylä with Postdoctoral Researcher funding from the Academy of Finland. Walker’s team also found links between the ability to sense […]
The implementation of a new U.S. kidney transplant allocation system did not solve many of the inequities that low-income and minority kidney disease patients face, Drexel University College of Medicine researchers found in a new study published recently in the journal Clinical Transplantation. The study strengthens the argument that early disease diagnosis and preemptive waitlisting […]
MIT researchers are employing novel machine-learning techniques to improve the quality of life for patients by reducing toxic chemotherapy and radiotherapy dosing for glioblastoma, the most aggressive form of brain cancer. Glioblastoma is a malignant tumor that appears in the brain or spinal cord, and prognosis for adults is no more than five years. Patients […]
Studying transthyretin amyloidoses-a group of progressive nerve and cardiac degenerative diseases caused by the buildup of misfolded transthyretin (TTR) proteins in the body-has long been hampered by the lack of animal models of the disease. Mice, for instance, don’t show the same symptoms as humans, even when misfolded TTR accumulates in their organs. Now, scientists […]
Doxorubicin is a chemotherapy drug widely used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. University of Alabama at Birmingham researchers now describe an important contributor to that heart pathology—disruption of the metabolism that […]
Building on their development of the first culture system to replicate fully the pathology behind Alzheimer’s disease, a Massachusetts General Hospital (MGH) research team has now produced a system that includes neuroinflammation, the key biological response that leads to the death of brain cells. The investigators describe their system, which incorporates the glial cells that […]
They found that immunoglobulin A (IgA) antibodies released by the gut can alter how bacteria express their genes. This encourages the microorganisms to form communities that work together to defend against disease and safeguard the health of their “host.” Antibodies are involved in the immune response and have long been recognized as fighters of harmful […]