As reported in Nature Communications, researchers from Cleveland Clinic’s Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression.Ulcerative colitis is […]
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Meeting India’s air quality targets across south Asia may prevent 7% of pregnancy losses, modelling study estimates
Poor air quality is associated with a considerable proportion of pregnancy loss in India, Pakistan, and Bangladesh, according to a modelling study published in The Lancet Planetary Health journal. Previous studies have suggested a link between air pollution and pregnancy loss in other regions, but this is the first study to quantify the burden in […]
Experts call for Europe-wide COVID-19 targets
A group of more than 300 leading scientists across the globe are calling for European governments to work together in managing the pandemic and make a clear commitment to COVID-19 case number targets. The letter, co-authored by Dr. Deepti Gurdasani from Queen Mary University of London and coordinated by Viola Priesemann from the Max Planck […]
The reason Target’s $10 million donation is so important
A high profile name has come forward to pledge financial support not just to groups working towards social justice, but also to help rebuild Minnesota’s riot-torn Twin Cities. Target, whose headquarters is in Minneapolis, has announced that it will support its long-standing partners like the National Urban League and the African American Leadership Forum. They […]
Target's New LEGO Sale is a Boon for Indoor-Learning Kids Everywhere
When it comes to picking out toys, we’re always mindful that they not just keep our little ones entertained for hours on end, but that they’re teaching them valuable life skills at the same time. LEGO kits are one of the best ways to meet both of those requirements, and one of our closest friends […]
'Not a single country' on course to meet obesity targets by 2025
‘Not a single country’ is on course to meet World Health Organization targets to REVERSE spiralling obesity rates – and experts warn the UK and US have a ‘zero chance’ of curbing the epidemic by 2025 Countries are ‘worryingly off-track’, World Obesity Federation report says There is a less than a 10% chance the world […]
Novel drug targets tumor growth in advanced kidney cancer
Scientists report promising activity of a novel drug that targets a key molecular driver of clear cell renal cell carcinoma in patients with metastatic disease. Researchers from Dana-Farber Cancer Institute report a response rate of 24 percent across all risk categories of patients given an oral first-in-class agent that targets hypoxia inducible factor (HIF) 2-a, […]
Immune system targets vitamin B12 pathway to neutralize bacteria
Close to 1.8 billion people worldwide are infected with Mycobacterium tuberculosis (Mtb), the common and occasionally deadly bacterium that causes millions of cases of tuberculosis each year. The bacteria, having coevolved with humans over millennia, have devised ways of hijacking nutrients from its human host for its own benefit. Humans have equally complex ways of […]
Study targets ‘fingerprint’ of human consciousness
Western researchers have moved a step closer to identifying a ‘brain fingerprint’ for consciousness—a discovery that will unlock further understanding into why some patients, presumed to be vegetative, are still aware of the world them. In his landmark 2006 study, Western neuroscientist Adrian Owen and his collaborators showed for the first time that functional neuroimaging […]
Uncovering new therapeutic targets for airway inflammation in sickle cell disease
A new study by De, Agrawal, Morrone et al, chal-lenges the common notion that airway inflammation in Sickle Cell Disease (SCD) is secondary to asthma, even though the two disorders often coexist. In a recent pilot, cross sectional study, both systemic and airway inflammatory markers were compared in patients with sickle cell disease with and […]