Health Problems

CAR-T immunotherapies may have a new player

Emerging CAR-T immunotherapies leverage modified versions of patient’s T-cells to target and kill cancer cells. In a new study, published June 28 online in Cell Stem Cell, researchers at University of California San Diego School of Medicine and University of Minnesota report that similarly modified natural killer (NK) cells derived from human induced pluripotent stem […]

Health Problems

Complexity of NMDA receptor drug discovery target revealed

Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression. NMDA receptors, critical for learning and memory, are sensors in the brain. Studying them in molecular detail is challenging, because they usually come in four parts, and the parts aren’t all the same. Researchers at […]

Health Problems

Novel drug therapy partially restores hearing in mice

A small-molecule drug is the first to preserve hearing in a mouse model of an inherited form of progressive human deafness, report investigators at the University of Iowa, Iowa City, and the National Institutes of Health’s National Institute on Deafness and Other Communication Disorders (NIDCD). The study, which appears online in Cell, sheds light on […]

Health Problems

Azithromycin cuts pulmonary exacerbation in CF with early Pseudomonas aeruginosa

(HealthDay)—For children with cystic fibrosis (CF) and early Pseudomonas aeruginosa (Pa) infection, the risk of pulmonary exacerbation is significantly reduced with the addition of azithromycin to tobramycin inhalation solution (TIS), according to a study published online June 11 in the American Journal of Respiratory and Critical Care Medicine. Nicole Mayer-Hamblett, Ph.D., from the University of […]

Health Problems

‘Music of speech’ linked to brain area unique to humans

We humans are the only primates that can flexibly control the pitch of our voices. This melodic control is not just important for our singing abilities: Fluctuating pitch also conveys critical information during speech—including the speaker’s mood, words of emphasis, or whether a sentence is a statement or a question. Some tonal languages, like Mandarin […]

Health Problems

Men with migraine may have higher estrogen levels

While it has been known that estrogen plays a role in migraine for women, new research shows that the female sex hormone may also play a role in migraine for men, according to a small study published in the June 27, 2018, online issue of Neurology, the medical journal of the American Academy of Neurology. […]

Health Problems

Change in brain cells linked to opiate addiction, narcolepsy

Two discoveries—one in the brains of people with heroin addiction and the other in the brains of sleepy mice—shed light on chemical messengers in the brain that regulate sleep and addiction, UCLA researchers say. In 2000, UCLA researchers discovered that human narcolepsy is caused by a loss of roughly 90 percent of the 80,000 brain […]