Aagenaes syndrome is a rare disorder characterized by impaired bile flow from the liver resulting in cholestasis. Image Credit: Magic Mine/Shutterstock.com Blockage of bile secretion (hepatic cholestasis) results in swelling and fluid retention (lymphedema) in the lower extremities. Neonatal cholestasis in patients with Aagenaes syndrome usually diminishes during early childhood, but remains intermittent in nature. […]