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A new study published today demonstrates that a technology developed at the University of Central Florida could serve as a more reliable clinically-based model of amyotrophic lateral sclerosis (ALS) and a better screening tool for novel therapies than currently use preclinical models. The Human-on-a-Chip technology was developed by UCF Professor James J. Hickman in his […]
An experimental drug for a rare, inherited form of amyotrophic lateral sclerosis (ALS) has shown promise in a phase 1/phase 2 clinical trial conducted at Washington University School of Medicine in St. Louis, Massachusetts General Hospital in Boston and other sites around the world and sponsored by the pharmaceutical company Biogen Inc. The trial indicated […]
An experimental drug for a rare, inherited form of amyotrophic lateral sclerosis (ALS) has shown promise in a phase 1/phase 2 clinical trial conducted at Washington University School of Medicine in St. Louis, Massachusetts General Hospital in Boston and other sites around the world and sponsored by the pharmaceutical company Biogen Inc. The trial indicated […]
Researchers at Oregon State University have made an important advance toward understanding why certain cells in the nervous system are prone to breaking down and dying, which is what happens in patients with ALS and other neurodegenerative disorders. The study into the role a protein known as heat shock protein 90 plays in intracellular signaling […]
Amyotrophic lateral sclerosis, or ALS, is an adult-onset neurodegenerative disease that causes paralysis and ultimately death when the nerves enervating the lungs cease to carry the signals needed for breathing. The disease has what is called a “focal onset,” where paralysis starts with an arm or a leg and spreads throughout the body as motor […]
Virginia Tech Carilion Research Institute scientists have shown that mutations in specific genes that destroy motor neurons and thereby cause the devastating effects of amyotrophic lateral sclerosis— also known as ALS or Lou Gehrig’s disease—also attack sensory neurons. The discovery in today’s Scientific Reports indicates that studying sensory neurons could provide new mechanistic insights to […]