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Researchers at Weill Cornell Medicine have discovered how drugs can affect various membrane-spanning proteins in addition to their intended target, potentially causing unwanted side effects. The results illuminate one of the central problems of drug discovery and point to new strategies for solving it. Any class of drug can have side effects, but those that […]
To better understand the role of bacteria in health and disease, National Institutes of Health researchers fed fruit flies antibiotics and monitored the lifetime activity of hundreds of genes that scientists have traditionally thought control aging. To their surprise, the antibiotics not only extended the lives of the flies but also dramatically changed the activity […]
Researchers from Ben-Gurion University (BGU), together with American and German colleagues, have developed new "molecular tweezers" to combat antibiotic-resistant bacteria. Their recently announced findings were published in Cell Chemical Biology. For years, medical professionals have struggled with bacterial infections becoming increasingly resistant to antibiotics. These molecular tweezers may be the key to battling one of […]
Liver disease, from metabolic and bacterial causes, is a growing concern. What connects these dots? The gut, or more specifically, bacteria in the gut. Bacteria that cause inflammation in the mouth are transported through the digestive tract to the gut and liver, where they can cause liver inflammation. Lipopolysaccharides, important structural molecules in some bacteria, […]
Humans are creating or exacerbating the environmental conditions that could lead to further pandemics, new University of Sydney research finds. Modeling from the Sydney School of Veterinary Science suggests pressure on ecosystems, climate change and economic development are key factors associated with the diversification of pathogens (disease-causing agents, like viruses and bacteria). This has potential […]
The cocktail of beneficial bacteria passed from mother to infant through breast milk changes significantly over time and could act like a daily booster shot for infant immunity and metabolism. The research, conducted by scientists from Montreal and Guatemala and published in Frontiers in Microbiology, has important implications for infant development and health. Researchers discovered […]
While most adults over 50 understand that overuse of antibiotics is a problem, and say they're cautious about taking the drugs, a sizable minority have used antibiotics for something other than their original purpose, and appear to think the drugs could help treat colds, which are caused by viruses not bacteria. These findings, contained in […]
Skip to: What is CVID? What is the prevalence of CVID? What are the causative factors? How CVID is inherited? What are the common symptoms? How is CVID diagnosed? How is CVID treated? Common variable immune deficiency (CVID) is a genetic disorder characterized by a weakened immune system. Patients with CVID frequently suffer from infections. […]
Parkinson’s disease (PD) is treated by levodopa, which is a prodrug capable of crossing the blood-brain barrier before being metabolized to dopamine, a vital neurotransmitter in the brain. However, certain gut bacteria interfere with this treatment, leading to unpredictable fluctuations in the motor response to levodopa and pushing up the dosage levels unnecessarily. Image Credit: […]
In many ways, our brain and our digestive tract are deeply connected. Feeling nervous may lead to physical pain in the stomach, while hunger signals from the gut make us feel irritable. Recent studies have even suggested that the bacteria living in our gut can influence some neurological diseases. Modeling these complex interactions in animals […]