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UT Southwestern scientists have developed a new method to study the molecular characteristics of T cells, critical immune cells that recognize and attack invaders in the body such as viruses, bacteria, and cancer. The approach, described today in the journal Nature Methods, enables researchers to more easily analyze the roles of T cell receptors (TCRs)—the […]
A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets. The findings are published in eLife and may be relevant for […]
A new research study from the March of Dimes Prematurity Research Center led by investigators at the University of Chicago has identified new genetic markers associated with gestational length, providing new insights into potential risk factors for preterm birth. In a collaboration between multiple labs and funded through the March of Dimes Foundation, the investigators […]
Memories are part of our lives, the good and the bad. Through our senses, experiences reach our brain where networks of nerve cells encode them into a memory. It was previously unclear why only certain nerve cells join together for this purpose. Researchers from the Max Planck Institute of Psychiatry in Munich have now discovered […]
As researchers and medical professionals work to develop new treatments for cancer, they face a variety of challenges. One is intratumor heterogeneity—the presence of multiple kinds of cancer cells within the same tumor. Often, these “mosaic” tumors include cells, such as polyploidal giant cancer cells, that have evolved to become aggressive and resistant to chemotherapy […]
Researchers at the UCLA Jonsson Comprehensive Cancer Center have found that a drug that activates the body’s natural defenses by behaving like a virus may also make certain stealthy melanoma tumors visible to the immune system, allowing them to be better targeted by immunotherapy. The findings, published today in the journal Science Translational Medicine, open […]
A type of anti-bacterial T cells, so-called MAIT cells, are strongly activated in people with moderate to severe COVID-19 disease, according to a study by researchers at Karolinska Institutet in Sweden that is published in the journal Science Immunology. The findings contribute to increased understanding about how our immune system responds against COVID-19 infection. “To […]
Allogenic hematopoietic stem cell transplantation (HSCT) is a procedure that infuses a donor’s healthy blood-forming stem cells into a recipient as part of a potentially curative therapy for cancer. While this therapy can be life-saving, a major complication is the development of graft-versus-host disease (GVHD), which causes significant morbidity and can be fatal. Before allogenic […]
If anything happens to the eyes of the tiny, freshwater-dwelling planarian Schmidtea mediterranea, they can grow them back within just a few days. How they do this is a scientific conundrum—one that Peter Reddien’s lab at Whitehead Institute has been studying for years. The lab’s latest project offers some insight: in a paper published in […]
Prof. Euisik Yoon’s research group has developed a new, faster method to identify cancer stem-like cells (CSCs), which could help improve the effectiveness of cancer treatments. CSCs can seed and develop tumors in metastatic sites, causing cancer to relapse in patients after treatment. They are also generally resistant to chemotherapy and radiotherapy, so therapeutics that […]