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Hair follicle miniaturization was a prominent feature of persistent chemotherapy-induced alopecia (pCIA) in breast cancer survivors who presented to four specialty hair clinics, and treatment with minoxidil (sometimes with antiandrogen therapy) was associated with improved hair density, according to a recently published retrospective case series. “An improvement in hair density was observed in most of the […]
The chemotherapy drug cisplatin is an effective cancer treatment for many children with cancer, but unfortunately it can cause permanent hearing loss. Results from a new study show that the hearing of very young children is impacted early during treatment and is affected to a greater extent than that of older children. The findings are […]
NEW YORK (Reuters Health) – In patients with non-small cell lung cancer brain metastases (NSCLCBM) treated with immune-checkpoint inhibitors (ICIs) and upfront steroids, a low neutrophil-to-lymphocyte ratio (NLR) was associated with lower overall survival in a single-center retrospective analysis. “With widespread implementation of ICIs for treatment of NSCLC, many clinicians have concerns that the immunosuppressive […]
The combination of copanlisib plus rituximab led to a 48% reduction in the risk of disease progression or death, when compared with rituximab plus placebo in a phase 3 trial of patients with relapsed, indolent non-Hodgkin lymphoma (NHL). The trial, dubbed CHRONOS-3, is the first to report “a broad benefit” across histologic subtypes of relapsed, indolent […]
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell "poor" to T cell […]
Skip to: What are tumorspheres? Tumorsphere formation assay Technical notes on tumorsphere cultivation What are the types of cancer stem cell (CSC) tumorspheres? Tumorspheres for screening anti-CSC drugs What is the future of tumorspheres? What are tumorspheres? Numerous studies have pointed out that cancer stem cells (CSCs) play an important role in cancer progression, metastasis, […]
Researchers at Children’s Medical Research Institute have demonstrated why chemotherapy drugs work better with some types of cancers than with others. Dr. Pragathi Masamsetti, the lead author of a new paper published in Nature Communications, has been studying the pathways of cell death caused by chemotherapy drugs for the past five years after a surprise […]
University of Colorado Cancer Center led clinical trial data show that a predictive tool called COXEN may show which bladder cancer patients will respond to pre-surgical chemotherapy, a step towards allowing doctors to offer such chemotherapy to patients likely to respond, while moving more efficiently to other treatment options with patients unlikely to benefit. Results […]
The first test to quickly and accurately predict how people will respond to standard treatment for the most common type of leukaemia has been developed at Cardiff University. The technology could guide doctors’ decisions on which drugs to give to patients. The Cardiff researchers say that the test could now be a ‘game changer’ in […]
Due to their powerful tumour-killing effect, metal-based chemotherapies are frequently used in cancer treatment. However, it was hitherto assumed that they damaged the immune system, because of their cytotoxic (cell-damaging) effect even against dividing healthy cells. In a scientific review produced by the Translational Cancer Therapy Research cluster, established by the University of Vienna and […]