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SARS-CoV-2 ORF8 and the expression of cytokine in human macrophages

The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by the rapid spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). SARS-CoV-2, which was first reported in Wuhan, China in 2019, is a positive-sense ribonucleic acid (RNA) virus belonging to the family Coronaviridae. Study: Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages. […]

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Immunogenicity of mRNA vaccine against emerging strains of SARS-CoV-2 in immunocompromised patients

Immunocompromised individuals who are also of older age, obese, and/or have cardiovascular disease are at a greater risk of developing severe cases of the coronavirus disease 2019 (COVID-19) that can even lead to death. In addition, disease-specific factors including disease activity and treatments, particularly those that include glucocorticoid, mycophenolate mofetil, and/or rituximab, are also risk […]