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First results from a clinical trial of a procedure to open obstructed airways in patients with chronic obstructive pulmonary disease (COPD) have shown that it significantly reduces problems associated with the disease and is safe. Presenting findings from the AIRFLOW 2 phase II clinical trial, the principal investigator, Dr Dirk-Jan Slebos, from the University Medical […]
Women receiving silicone breast implants may be at increased risk of several rare adverse outcomes compared to the general population, reports a study in Annals of Surgery. “We are reporting an analysis of the largest prospective study to date on silicone breast implant safety,” comments Mark W. Clemens, MD, and colleagues of The University of […]
As we go about our daily lives, we are exposed to many different chemicals that could have negative effects on our hormones. These hormonal changes have been linked to several adverse health outcomes such as breast cancer and cardiovascular disease. Therefore, understanding chemicals that influence hormone levels is important for public health — and particularly […]
In a new invited review article, ASU Biodesign microbiologists and tissue engineers Cheryl Nickerson, Jennifer Barrila and colleagues discuss the development and application of three-dimensional (3-D) tissue culture models as they pertain to infectious disease. They describe these models as predictive pre-clinical platforms to study host-pathogen interactions, infectious disease mechanisms, and antimicrobial drug development. The […]
As a veterinarian, Dr. Carolyn Duregger is familiar with the telltale signs of canine melanoma. So when she gave her own dog, Parker, a routine oral examination, the 1-centimeter-diameter discolored lump in the pup’s upper right gums took her breath away. “It’s an aggressive cancer with poor prognosis that I’ve seen many times. My stomach […]
Much of modern Western medicine is based upon the treatment of acute, immediate harm, from physical injury to infections, from broken bones and the common cold to heart and asthma attacks. But progress in treating chronic illness, where the cause of the problem is often unknown — and, in fact, may no longer even be […]
Our immune system is working every day to protect us from bacteria, viruses, and parasites, but it can also detect when our own cells are damaged. Research led by Lancaster University has now discovered how skin cells alert the immune system, when their DNA is damaged in the absence of infection. This DNA damage can […]
Statins are not associated with a reduction in cardiovascular disease (conditions affecting the heart and blood vessels) or death in healthy people aged over 75, finds a study published by The BMJ today. However, in those with type 2 diabetes, statins were related to a reduction in cardiovascular disease and death from any cause up […]
A groundbreaking discovery by chemists at The University of Texas at San Antonio (UTSA) will have a significant impact on how pharmaceutical companies develop new drug treatments. The breakthrough involves fluorine, which forms the second strongest carbon bond (C-F) known to science, after the carbon-silicon (C-S) bond. Fluorine is one of the most fundamental elements […]
The overall mortality in patients suffering non-neonatal tetanus is high. Efforts to reduce mortality in one sub-Saharan African intensive care unit (ICU) by implementing a standard tetanus protocol did little to change mortality rates, although they shifted causes of deaths, researchers have now reported in PLOS Neglected Tropical Diseases. Tetanus is a vaccine-preventable neglected disease […]