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New research reveals how healthy cells in our bodies produce mucins — the main component of mucous, which protects our intestine and airway from pathogens, toxins and allergens. Scientists have already linked defects in mucins secretion to airway and colonic diseases, such as asthma or ulcerative colitis. Now, researchers at Malhotra’s laboratory in Barcelona, reveal […]
Inside the cell, DNA is tightly wrapped around proteins and packed in a complex, 3D structure that we call “chromatin.” Chromatin not only protects our genetic material from damage, but also organizes the entire genome by regulating the expression of genes in three dimensions, unwinding them to be presented to the cell’s gene-expression machinery and […]
Cancer of the esophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it’s often too late to save the patient. A Johns Hopkins researcher who has devoted his career to the detection and prevention of esophageal cancer […]
An international team of researchers have carried out a review of the evidence examining what influences people who are HIV positive to go to health services and then stay on antiretroviral drugs in Africa. In a paper published in the Journal PLOS One the team, led by LSTM’s Professor Paul Garner, used advanced methods of […]
In recent years, an overwhelming body of clinical evidence has firmly established the HIV Undetectable = Untransmittable (U=U) concept as scientifically sound, say officials from the National Institutes of Health. U=U means that people living with HIV who achieve and maintain an undetectable viral load — the amount of HIV in the blood — by […]
Why is it so challenging to increase the number of people who get vaccinated? How does popular resistance to vaccination remain strong even as preventable diseases make a comeback? A new study from Dartmouth College shows that past problems with vaccines can cause a phenomenon known as hysteresis, creating a negative history that stiffens public […]
Recent breakthroughs in immunotherapy are making a huge difference in treating some forms of cancer, especially metastatic cancer. But breast cancer has proven a tricky foe for this new therapy, and an interdisciplinary team of FSU researchers is now a little bit closer to figuring out why. Associate Professor of Statistics Jinfeng Zhang, Professor of […]
New research from the University of Adelaide’s Robinson Research Institute supports the need for dietary and lifestyle interventions before overweight and obese women become pregnant. The researchers have reported the results of a large study of birth outcomes in more than 500 overweight or obese women from three public maternity units in Adelaide, Australia in […]
Pneumonia, a respiratory disease that kills about 50,000 people in the United States every year, can be caused by many different microbes, including bacteria and viruses. Rapid detection of pneumonia is critical for effective treatment, especially in hospital-acquired cases which are often more severe. However, current diagnostic approaches often take several days to return definitive […]
Scientists from Sanford Burnham Prebys Medical Discovery Institute (SBP) have identified gene recombination in neurons that produces thousands of new gene variants within Alzheimer’s disease brains. The study, published today in Nature, reveals for the first time how the Alzheimer’s-linked gene, APP, is recombined by using the same type of enzyme found in HIV. Using […]