Human stem cells are of great interest in the fields of regenerative medicine and medical research because they reproduce indefinitely and can differentiate into every other cell type found in the body. While stem cells naturally occur in very few places in the adult body, induced pluripotent stem cells (iPS cells) can be produced directly […]
Unique brain ‘fingerprint’ can predict drug effectiveness
Personalized medicine—delivering therapies specially tailored to a patient’s unique physiology—has been a goal of researchers and doctors for a long time. New research provides a way of delivering personalized treatments to patients with neurological disease. Researchers at the Montreal Neurological Institute and Hospital (The Neuro) of McGill University and the Ludmer Centre for Neuroinformatics and […]
‘Amazingly protective’ drug may STOP the progression of Parkinson’s
Is a cure for Parkinson’s on the horizon? Experimental drug STOPS its progress and can combat its symptoms, promising trials show Early trials on mice and in the lab showed NLY01 stopped brain cells dying Parkinson’s strikes 120,000 patients in the UK and one million in the US It gradually destroys cells in the part […]
Complexity of NMDA receptor drug discovery target revealed
Know your target. Especially if your target is coming into focus for treating diseases such as schizophrenia and treatment-resistant depression. NMDA receptors, critical for learning and memory, are sensors in the brain. Studying them in molecular detail is challenging, because they usually come in four parts, and the parts aren’t all the same. Researchers at […]
Novel drug therapy partially restores hearing in mice
A small-molecule drug is the first to preserve hearing in a mouse model of an inherited form of progressive human deafness, report investigators at the University of Iowa, Iowa City, and the National Institutes of Health’s National Institute on Deafness and Other Communication Disorders (NIDCD). The study, which appears online in Cell, sheds light on […]
Progress toward improved Wilson’s disease drug
Researchers at Cold Spring Harbor Laboratory (CSHL), working in collaboration with DepYmed Inc., a CSHL spinout company, today report that they have conducted promising preclinical experiments on a compound that could be used to treat Wilson’s disease and possibly other disorders—including certain types of cancer—in which levels of copper in the body are elevated, causing […]