Everyone feels tired at times, but up to 20 percent of U.S. adults report feeling so sleepy during the day that it interferes with daily activities, including working, having meals or carrying on conversations. Excessive daytime sleepiness (EDS) can lead to car accidents and work-related injuries and may increase risk of stroke and heart disease. […]
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New biologically derived metal-organic framework mimics DNA
The field of materials science has become abuzz with “metal-organic frameworks” (MOFs), versatile compounds made up of metal ions connected to organic ligands, thus forming one-, two-, or three-dimensional structures. There is now an ever-growing list of applications for MOF, including separating petrochemicals, detoxing water from heavy metals and fluoride anions, and recovering hydrogen or […]
Effects on offspring of epigenetic inheritance via sperm
As an organism grows and responds to its environment, genes in its cells are constantly turning on and off, with different patterns of gene expression in different cells. But can changes in gene expression be passed on from parents to their children and subsequent generations? Although indirect evidence for this phenomenon, called “transgenerational epigenetic inheritance,” […]
When less is more: A promising approach for low-cell-number epigenomic profiling
Scientists at Kyushu University and Tokyo Institute of Technology in Japan have developed a technique that enables analysis of DNA-protein interactions using very small numbers of cells, ranging from 100 to 1,000. Their method could capture previously unexamined epigenomic information, facilitate biomarker discovery and open new avenues for precision medicine. A collaborative study by researchers […]
Researchers wake-up DNA from soil bacteria to discover novel acid antibiotic
Scleric Acid has been discovered by capturing and engineering a DNA fragment from soil bacteria Streptomyces sclerotialus, and could help fight bacterial infections — by researchers at the School of Life Sciences and Department of Chemistry, University of Warwick. A team led by Dr Christophe Corre and Dr Manuela Tosin have had published in Chemical […]
New insights into DNA phase separation
“Each human cell contains approximately 2 meters of DNA, yet that are too small to be visible to the unaided eye. Amazingly, all of that DNA is tightly packaged into a teeny little nucleus. There, we were able to observe the most basic separation principle of oil and water phases.” A new study by Professor […]