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Heavy alcohol consumption (three drinks or more/day for women and four drinks or more/day for men) is linked to alterations in immune function among people with HIV. While it has been known that alcohol impacts immune function, it’s been unclear the effect of alcohol on immune function in the context of HIV, a disease whose […]
A team of scientists from Weill Cornell Medicine and The Rockefeller University has illuminated the basic mechanism of Piezo proteins, which function as sensors in the body for mechanical stimuli such as touch, bladder fullness, and blood pressure. The discovery is a feat of basic science that also opens up many new paths of investigation […]
Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death. Scientists at Cincinnati Children’s Hospital Medical Center report in the American Journal of Respiratory and Critical […]
A Ludwig Cancer Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells. “We show that two key chemokines, CCL5 and CXCL9, are universally implicated in T cell infiltration across all solid tumors,” said George […]
A new study conducted at the University of Copenhagen challenges traditional knowledge of stem cell development. The study reveals that the destiny of intestinal cells is not predetermined, but instead determined by the cells’ surroundings. The findings may make it easier to manipulate stem cells for stem cell therapy. Results have just been published in […]
Induced pluripotent stem (iPS) cells are among the most important tools in modern biomedical research, leading to new and promising possibilities in precision medicine. To create them requires transforming a cell of one type, such as skin, into something of a blank slate, so it has the potential to become virtually any other kind of […]
How do bones heal, and how could they heal better? The answer to these questions may lie in a newly discovered population of “messenger” cells, according to a recent USC Stem Cell study published in the journal eLife. “With nearly half a million patients in the U.S experiencing failed bone repair every year, stimulating these […]
A new animal model developed by Massachusetts General Hospital (MGH) investigators promises to be less expensive, easier to use and to improve personalized therapies for cancers and potentially other diseases. In their paper published online in Cell, the investigators describe using their immunodeficient zebrafish model to visualize drug responses at single-cell resolution in live animals. […]
Human cells have a sophisticated regulatory system at their disposal: labeling proteins with the small molecule ubiquitin. In a first, a team from the Technical University of Munich (TUM) has succeeded in marking proteins with ubiquitin in a targeted manner, in test tubes as well as in living cells. The procedure opens the door to […]
Mayo Clinic researchers and their collaborators have shown that when senescent cells — also known as “zombie cells” — are removed from fat tissue in obese mice, severity of diabetes and a range of its causes or consequences decline or disappear. The findings appear in Aging Cell. Inflammation and dysfunction of fat tissue cause some […]