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Researchers at Erasmus University Medical Center in The Netherlands have explored how and why new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), have exhibited heightened infectivity. Study: Experimental evidence for enhanced receptor binding by rapidly spreading SARS-CoV-2 variants. Image Credit: Design_Cells / Shutterstock They suggest […]
By Shelley Farrar, MSc, BSc Cryo-electron microscopy, also known as Cryo-EM, is a technique for visualizing macromolecular structures which has been developed over the last two decades. It is a form of transmission electron microscopy which permits samples to be studied at cryogenic temperatures. Biological structures such as ribosomes and mitochondria from pathogens, ion channels […]
Two mutations identified in individuals with developmental and epileptic brain disease can be traced back to the same ion channel. Researchers have now elucidated how both independent mutations affect the channel’s function: by making it overly active and highly sensitive to stimulation. The findings are an important step towards unraveling what causes the patients’ symptoms. […]