Health News

Potential new therapies for Alzheimer’s are revealed through network modeling of its complex molecular interactions

Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment, according to a study in the journal Neuron. LOAD is the most prevalent form of dementia among people over age 65, a […]

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Novel PROTAC enhances its intracellular accumulation and protein knockdown

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation. Proteolysis-targeting chimeras or PROTACs are a promising type of protein-degrader molecules, but their effectiveness has been challenged by their limited ability to accumulate inside cells. In this study published in the journal Nature Communications, a […]

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Leaving its mark: How frailty impacts the blood

Globally, human society is aging. A side-effect of this is that age-related disorders, such as frailty, are becoming increasingly common. Frailty includes not only physical disabilities, but also a decline in cognitive function and an increase in various social problems. The prevalence of this disorder among those aged 65 and over is estimated at 120 […]