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In a study published in the Journal of Controlled Release, University of Kentucky Markey Cancer Center researchers used nanoparticles to deliver powerful chemotherapy drugs directly to lungs affected by metastatic disease while avoiding toxicity elsewhere in the body. The majority of anti-cancer therapeutics are effective at killing fast-growing cancer cells, but at a price – […]
Researchers have now grown lung organoids from human embryonic stem cells (hESCs) that, after implantation in mice, can develop mature alveolar type 1 (AT1) and AT2 cells and architecture approximating that of human lungs. The strategy is the first to generate both lung distal progenitor cells and mature AT1-like cells. The study is published in […]
Scientists have found that it is the structure of collagen, rather than the amount, that leads to the devastating condition of lung fibrosis, according to a report in the journal eLife. The study provides the first evidence in humans that altered collagen structure affects tissue stiffness during progression of lung fibrosis and identifies a potential […]