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Contrary to popular belief, there may be more than one mechanism involved in microbial airway protection. Researchers from Japan and China have found an alternative mechanism that may be involved in fighting microbial infections. The inflammation pathway in response to microbial infections involves multiprotein complexes known as inflammasomes. It is known that inflammasomes induce inflammation […]
Multiple sclerosis (MS) is an autoimmune disease in which the immune system turns on its own cells and attacks them for reasons that are not yet known. Scientists from the Institut Pasteur have shown that ancient viruses are involved in the acute inflammatory defense response that may contribute to the disease. Multiple sclerosis (MS) is […]
Jianzhong Chen, Ph.D., assistant professor at the University of Alabama at Birmingham School of Optometry, along with co-author Kelly Nichols, O.D., MPH, Ph.D., FAAO, dean of the School of Optometry, has published a sensitive method facilitating dry eye disease studies in the Journal of Lipid Research. JLR is the most cited lipid journal in the […]
A new mechanism for activating the immune system against cancer cells allows immune cells to detect and destroy cancer cells better than before, according to a study published this week in the journal Nature. The study was led by Prof. Nick Haining, of Harvard Medical School, and co-authored by Prof. Erez Levanon, doctoral student Ilana […]
Scientists have long known that circulating tumor cells, rare cancer cells that are released into the bloodstream, have the potential to provide vital information about a person’s specific cancer. But until now, they have been unable to reliably access information on how these cells behave. UCLA researchers have created a quick and effective mechanism to […]
RUDN biochemists suggested a new mechanism by which the human body prevents the development of autoimmune diseases, allergies and implant rejection. They report that regulatory T-cells are able to suppress the reproduction of autoimmune cells. The work was published in Molecular Immunology. The ability of the body to resist pathogenic factors is under the control […]
An international team of researchers has uncovered a destructive mechanism at the molecular level that causes a well-known phenomenon associated with obesity, called leptin resistance. They found that mice fed a high-fat diet produce an enzyme named MMP-2 that clips receptors for the hormone leptin from the surface of neuronal cells in the hypothalamus. This […]
There is a highly sophisticated way to treat some breast and ovarian cancers—a class of drugs called PARP inhibitors, designed to exploit the very defects that make tumors with certain mutations especially deadly. Yet this targeted approach to cancer therapy sometimes fails, and scientists have anxiously sought to understand why. Now, research at The Rockefeller […]
Researchers have recently begun to realize that biological sex plays a key role in disease risk. Sex plays a role in hypertension, diabetes, arthritis—and in many neurological and psychiatric disorders. Depression and anxiety affect females more, while neurodevelopmental disorders, including autism spectrum disorders, early onset schizophrenia, and attention deficit hyperactivity, affect more males. Males are […]