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Researchers from University Health Network have developed and validated an innovative deep learning model to predict a patient’s long-term outcome after receiving a liver transplant. First of its kind in the field of Transplantation, this model is the result from a collaboration between the Ajmera Transplant Centre and Peter Munk Cardiac Centre. The study, published […]
A two-week course of high doses of CBD helps restore the function of two proteins key to reducing the accumulation of beta-amyloid plaque, a hallmark of Alzheimer’s disease, and improves cognition in an experimental model of early onset familial Alzheimer’s, investigators report. The proteins TREM2 and IL-33 are important to the ability of the brain’s […]
A team of researchers led by a group at the Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, has found evidence suggesting that the U.K. variant of the SARS-CoV-2 virus could be 43 to 90% more transmissible than the original virus. In their study, published in the journal Science, […]
An article published by the American Society for Microbiology has outlined a general quantitative framework to determine the accuracy of in vitro and in vivo models used in microbiology research. The team evaluated the efficacy of their model using the bacterium Pseudomonas aeruginosa. Image Credits: Jun MT / Shutterstock.com The models used to assemble the […]
As reported in Nature Communications, researchers from Cleveland Clinic’s Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression.Ulcerative colitis is […]
Using stem cells to regenerate parts of the skull, scientists corrected skull shape and reversed learning and memory deficits in young mice with craniosynostosis, a condition estimated to affect 1 in every 2,500 infants born in the United States, according to the Centers for Disease Control and Prevention. The only current therapy is complex surgery […]
Alzheimer’s disease is characterized by the presence of amyloid plaques in the patient’s brain. These plaques sequester copper, and contain approximately five times as much as a healthy brain. Two CNRS scientists from the Coordination Chemistry Laboratory recently developed, with their colleagues from the Guangdong University of Technology and Shenzhen University (China), a molecule that […]
A new artificial intelligence-based algorithm may help clinicians predict which patients with COVID-19 face a high risk of developing acute kidney injury (AKI) requiring dialysis. The research will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. Preliminary reports indicate that acute AKI is common in patients with COVID-19. Using data from […]
The plant compound apigenin improved the cognitive and memory deficits usually seen in a mouse model of Down syndrome, according to a study by researchers at the National Institutes of Health and other institutions. Apigenin is found in chamomile flowers, parsley, celery, peppermint and citrus fruits. The researchers fed the compound to pregnant mice carrying […]
Interval cancer is the term used for colorectal cancer that develops after a screening colonoscopy but before the scheduled follow-up colonoscopy. These cancers are probably more frequent than assumed, especially in high-risk patients who have been found to have an initially benign but advanced adenoma. In a study now published in the journal Gut, Elisabeth […]