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Targeted agents for the treatment of diffuse large B-cell lymphoma (DLBCL) should be used in the context of oncogenic addictions within the lymphoma cells, and a thorough molecular analysis should be conducted prior to using specific agents, a review of the relevant literature suggests. “In addition … single-agent regimens are most likely not efficient enough […]
NEW YORK (Reuters Health) – Single-agent subcutaneous epcoritamab appears to benefit patients with relapsed or refractory B-cell non-Hodgkin lymphoma, results of an ongoing early trial suggest. Epcoritamab is “a novel bispecific antibody that targets CD3 and CD20 and induces T-cell-mediated cytotoxic activity against CD20+ malignant B cells,” the study team explains in The Lancet. “Epcoritamab […]
The combination of copanlisib plus rituximab led to a 48% reduction in the risk of disease progression or death, when compared with rituximab plus placebo in a phase 3 trial of patients with relapsed, indolent non-Hodgkin lymphoma (NHL). The trial, dubbed CHRONOS-3, is the first to report “a broad benefit” across histologic subtypes of relapsed, indolent […]