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A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein—coronavirus’ key entry point into nose and lung cells—it predominantly increases levels of a short version of that protein, which the virus cannot bind to. The virus that causes COVID-19, […]
Two mutations identified in individuals with developmental and epileptic brain disease can be traced back to the same ion channel. Researchers have now elucidated how both independent mutations affect the channel’s function: by making it overly active and highly sensitive to stimulation. The findings are an important step towards unraveling what causes the patients’ symptoms. […]
People with chronic obstructive pulmonary disease (COPD) and people who currently smoke may have higher levels of a molecule, called angiotensin converting enzyme II (ACE-2), in their lungs according to a study published in the European Respiratory Journal today. Previous research shows that ACE-2, which sits on the surface of lung cells, is the ‘entry […]
During big procedures like open heart surgery, patients need anticoagulants to prevent dangerous blood clot formation and regular bedside monitoring to make sure the drugs aren’t also causing problems like excessive bleeding. Investigators comparing some common bedside testing platforms to quickly determine how fast blood is clotting, called activated clotting time, or ACT, suggest other […]
From the DNA of nearly 300,000 veterans, scientists have singled out a handful of genetic mutations that not only govern levels of cholesterol, but may also inform the development and use of drugs for cardiovascular disease and diabetes, according to researchers at the Stanford University School of Medicine and the Palo Alto Veteran Affairs Health […]
Sexual health services are at ‘breaking point’ after 3.3million people visit clinics in one year The Tinder effect? Sexual health services are at ‘breaking point’ after 3.3million people visit clinics in one year, councils warn Sexual health services in England are ‘stretched to the limit’ 3.3million people visited clinics last year, council leaders are warning […]