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As researchers and medical professionals work to develop new treatments for cancer, they face a variety of challenges. One is intratumor heterogeneity—the presence of multiple kinds of cancer cells within the same tumor. Often, these “mosaic” tumors include cells, such as polyploidal giant cancer cells, that have evolved to become aggressive and resistant to chemotherapy […]
Japan has signed a deal to secure 120 million doses of a potential coronavirus vaccine, German pharmaceutical group BioNTech, which is developing the drug with US pharma giant Pfizer, said Friday. Financial details of the deal were not disclosed, with BioNTech saying the terms were based on the timing of the delivery and volume of […]
A new study identifies some of the most critical genes that may drive a rare but deadly liver cancer, providing a road map for developing drugs that target those genes. The cancer, fibrolamellar carcinoma, accounts for 1-5% of all liver cancers, and disproportionately affects children and young adults. By the time it is detected it […]
Researchers at the University of Maryland School of Medicine (UMSOM) developed a new nanoparticle drug formulation that targets a specific receptor on cancer cells, and appears to be more effective than a standard nanoparticle therapy currently on the market to treat metastatic breast cancer. The study, published today in the journal Science Advances, found that […]
The role of artificial intelligence, or machine learning, will be pivotal as the industry wrestles with a gargantuan amount of data that could improve—or muddle—health and cost priorities, according to a National Academy of Medicine Special Publication on the use of AI in health care. Yet, the current explosion of investment and development is happening […]
A critical question in medicine asks how individual variation in DNA can predict variation in health and disease. New research from the Clemson Center for Human Genetics identified hundreds of metabolites that might serve as intermediates to translate variation in the genome to variation in complex traits. Published recently in Genome Research, the findings could one day […]
Led by researchers at Baylor College of Medicine, a study published in the journal Cell Stem Cell reveals a new mechanism that contributes to adult bone maintenance and repair and opens the possibility of developing therapeutic strategies for improving bone healing. “Adult bone repair relies on the activation of bone stem cells, which still remain […]
Messy tangles of a protein called tau can be found in the brains of people with Alzheimer’s disease and some other neurodegenerative diseases. In Alzheimer’s, the tangles coalesce just before tissue damage becomes visible in brain scans and people start to become forgetful and confused. Now, a new study has found that brain immune cells […]
Amyotrophic lateral sclerosis, or ALS, is an adult-onset neurodegenerative disease that causes paralysis and ultimately death when the nerves enervating the lungs cease to carry the signals needed for breathing. The disease has what is called a “focal onset,” where paralysis starts with an arm or a leg and spreads throughout the body as motor […]
Having aspirations helps us navigate life in a meaningful and fulfilling way, but it can also cause psychological distress when hopes are left unfulfilled. New Edith Cowan University (ECU) research has found that it’s not failing to make progress toward our ‘ideal-self’ that is problematic but rather the tendency to focus on that lack of […]