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Early 2020 saw the world break into what has been described as a “war-like situation”: A pandemic, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the likes of which majority of the living generations across most of the planet have not ever seen. This pandemic has downed economies and resulted in hundreds of […]
The University of Alabama at Birmingham and Southern Research have discovered a new drug candidate that offers a major advance in the treatment for diabetes. Tested on isolated human and mouse pancreatic islets, mouse and rat cell cultures and animal models of both Type 1 and Type 2 diabetes, the experimental drug significantly improved four […]
A newly identified compound is a promising candidate for inhibiting the production of amyloids, the abnormal proteins that form toxic clumps, called fibrils, inside the brains of patients with Alzheimer’s disease. As published today in the Royal Society of Chemistry’s Chemical Communications, the compound—known as “C1″—uses a novel mechanism to efficiently prevent the enzyme gamma-secretase […]
A new discovery from a team led by Massachusetts Eye and Ear researchers may bring scientists a step closer to developing treatments that regrow the missing cells that cause hearing loss. In a new study, published online December 4, 2019, in Nature Communications, scientists report a new strategy to induce cell division in the mature […]
A signaling pathway that helps promote normal cell growth worsens a form of leukemia by taking control of another pathway better known for protecting cells from biological stress, a new study shows. The discovery that the NOTCH1 pathway takes control of heat shock transcription factor 1 (HSF1) signaling in T cell acute lymphoblastic leukemia, or […]