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Adults undergoing mitral valve surgery who have less than severe leakage of the tricuspid valve may benefit by having both valves repaired at the same time, including a decreased chance of severe tricuspid valve leakage in the future, according to late-breaking research presented today at the American Heart Association’s Scientific Sessions 2021. Heart valves are responsible for […]
Treating mice that have a Parkinson’s disease-causing mutation with a small molecule compound restores the removal of damaged mitochondria from their brain cells, shows a study published today in eLife. The findings may help explain what goes wrong in dopamine-producing brain cells in people with mutations that cause Parkinson’s disease. Parkinson’s disease is caused by […]
Neurons lack the ability to replicate their DNA, so they’re constantly working to repair damage to their genome. Now, a new study by Salk scientists finds that these repairs are not random, but instead focus on protecting certain genetic “hot spots” that appear to play a critical role in neural identity and function. The findings, […]
Treating tumors presents a tricky conundrum: a higher dose of radiation is more effective for treatment, but the higher the dose, the more danger it poses to healthy cells. Researchers at Yale have made significant inroads into solving this problem in a paper titled, “LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to […]
Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver, according to the peer-reviewed journal Human Gene Therapy. The study was done in a mouse model of […]
It’s a fact of life that things break down. And when they do, whether it’s your car, the roof, or a blocked artery, there are people who we can call to help with the repairs. A lesser known fact of life is that DNA also regularly breaks down and needs to be repaired. Researchers led […]
A major international study has shown that opening all clogged arteries with stents after a serious heart attack is much better than opening only the single clogged artery that caused the heart attack. About half of all heart attack victims are found to have additional clogged arteries in addition to the one that caused their […]
Scientists at the German Center for Neurodegenerative Diseases (DZNE) have identified a group of proteins that help to regenerate damaged nerve cells. Their findings are reported in the journal Neuron. It is commonly accepted that neurons of the central nervous system shut down their ability to grow when they no longer need it; this occurs […]
A study by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore has revealed that RUNX proteins are integral to efficient DNA repair via the Fanconi Anemia (FA) pathway. Led by Professor Yoshiaki Ito, Senior Principal Investigator at CSI Singapore, and involving Senior Research Scientist Dr. Vaidehi Krishnan […]