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Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumour immune response. The preclinical research, published today in Nature Immunology, suggests that […]
A comparison of two key research tools used by immunologists to study different types of T-cell receptor signals has identified important features of existing technologies that could allow scientists to better understand immune responses, in a new study led by scientists at the University of Birmingham. T cells form a crucial part of the immune […]
A team of researchers affiliated with multiple institutions in Germany has found that T-cell specificity plays a major role in immune system attacks on myelin versus β-synuclein in people with multiple sclerosis. In their paper published in the journal Nature, the group describes their study of T-cell behavior in rat models and what they learned. […]
NIBIB-funded researchers have transformed T cells into drug factories engineered to find cells carrying specific diseases in the body—and then produce therapeutic proteins localized to the diseased cells. Senior author Parijat Bhatnagar, Ph.D., director of cell-based medicine at the SRI International Center for Chemical Biology, Menlo Park, California, and his colleagues engineered the T-cell “biofactories” […]