Use of a cosmetic laser invented at Massachusetts General Hospital (MGH) may improve the effectiveness of certain anti-tumor therapies and extend their use to more diverse forms of cancer. The strategy was tested and validated in mice, as described in a study published in Science Translational Medicine. Immune checkpoint inhibitors are important medications that boost […]
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Big data powers design of ‘smart’ cell therapies for cancer
Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research. In two new papers, scientists at UC San Francisco and Princeton University present complementary strategies to crack this problem with “smart” cell therapies—living medicines that remain inert unless triggered by combinations of proteins that only ever […]
Potential new therapies for Alzheimer’s are revealed through network modeling of its complex molecular interactions
Researchers from Mount Sinai and the National Center for Geriatrics and Gerontology in Japan have identified new molecular mechanisms driving late-onset Alzheimer’s Disease (LOAD), as well as a promising therapeutic candidate for treatment, according to a study in the journal Neuron. LOAD is the most prevalent form of dementia among people over age 65, a […]
Gut microbiome may influence how cancer patients respond to oral therapies, study suggests
A new study from Lawson Health Research Institute and Western University illustrates how the gut microbiome interacts with an oral medication in prostate cancer patients, suggesting bacteria in the gut play a role in treatment outcomes. The findings, published in Nature Communications, highlight how the drug abiraterone acetate is metabolized by bacteria in the gut […]
Review raises questions about family violence therapies
The comprehensive systematic review and meta-analysis of the effectiveness of psychological therapies for women who experience intimate partner violence (IPV) and abuse is published by the Cochrane Database of Systematic Reviews. Research Fellow at the University’s Safer Families Center of Research Excellence, Dr. Mohajer Hameed, worked on the review with others, including Professor Kelsey Hegarty […]
Therapies show knockout potential for rare, deadly liver cancer
A new study identifies some of the most critical genes that may drive a rare but deadly liver cancer, providing a road map for developing drugs that target those genes. The cancer, fibrolamellar carcinoma, accounts for 1-5% of all liver cancers, and disproportionately affects children and young adults. By the time it is detected it […]
Natural antioxidant helps improve immune-based therapies by modulating T-cells
Shikhar Mehrotra, Ph.D. and Xue-Zhong Yu, M.D., National Institutes of Health-funded researchers at the Medical University of South Carolina (MUSC), have discovered a way to improve immune-based treatments, such as adoptive T-cell therapy (ACT) and hematopoietic stem cell transplantation (HSCT), by modulating T-cells with thioredoxin, a powerful, naturally occurring antioxidant molecule. ACT is a cancer […]
The role of family doctors in advanced therapies
A recent study conducted jointly by the Tissue Engineering Research Group of the Department of Histology and the family medicine Unit of the University of Granada (UGR) has highlighted the conceptual, attitudinal and procedural profile of resident hospital doctors specialising in family medicine in relation to advanced therapies. According to the European Medicines Agency, cell […]
Guidance offered for managing therapies in children with disability
(HealthDay)—In a clinical report published online March 25 in Pediatrics, guidance is provided for managing therapy services for children with disabilities. Amy Houtrow, M.D., Ph.D., M.P.H., from the University of Pittsburgh, and colleagues offer information about how best to manage the therapeutic needs of children with temporary or permanent disabilities in the medical home. According […]
Scientists home in on microRNA processing for novel cancer therapies
More than a decade of research on the mda-7/IL-24 gene has shown that it helps to suppress a majority of cancer types, and now scientists are focusing on how the gene drives this process by influencing microRNAs. Published this week in the journal Proceedings of the National Academy of Sciences, the findings could potentially have […]