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A retrospective study conducted by scientists from the Comprehensive Cancer Center (CCC) of MedUni Vienna and Vienna General Hospital found that compiling a tumor molecular profile can result in better risk stratification and hence to better treatment decisions in endometrial cancer. The use of so-called “integrated molecular risk classification” could reduce the use of chemo- […]
Giving early-stage pancreatic cancer patients a CD40 immune-stimulating drug helped jumpstart a T cell attack to the notoriously stubborn tumor microenvironment before surgery and other treatments, according to a new study from researchers in the Abramson Cancer Center (ACC) at the University of Pennsylvania. Changing the microenvironment from so-called T cell "poor" to T cell […]
Thought LeadersProfessor Mark McGurkDirector of the Head and Neck Academic CentreUniversity College London Hospital Professor Mark McGurk speaks to News-Medical about his groundbreaking research that has led to the discovery of a world-first treatment for oral cancer. What inspired your research into head and neck cancer? I have been working on head and neck cancer […]
NEW YORK (Reuters Health) – Researchers have discovered a new type of bone cells, called “osteomorphs,” which may be targeted for osteoporosis and other skeletal diseases. The discovery came when Dr. Tri Giang Phan of the Garvan Institute of Medical Research in Darlinghurst, New South Wales and colleagues were studying osteoclasts, cells that resorb bone. […]
Rituximab, an anti-cancer drug targeting the membrane protein CD20, was the first approved therapeutic antibody against B tumor cells. Immunologists at the University of Freiburg have now solved a mystery about how it works. A team headed by Professor Dr. Michael Reth used cell cultures, healthy cells, and cells from cancer patients to investigate how […]
Skip to: What are tumorspheres? Tumorsphere formation assay Technical notes on tumorsphere cultivation What are the types of cancer stem cell (CSC) tumorspheres? Tumorspheres for screening anti-CSC drugs What is the future of tumorspheres? What are tumorspheres? Numerous studies have pointed out that cancer stem cells (CSCs) play an important role in cancer progression, metastasis, […]
A pair of copper radionuclides that target the somatostatin receptor overexpressed in neuroendocrine tumors has proven successful in identifying tumors and improving survival. According to new research published in the December issue of The Journal of Nuclear Medicine, the imaging agent 64Cu-CuSarTate produced high-quality positron emission tomography (PET) images in a mouse model of neuroendocrine […]
Treating tumors presents a tricky conundrum: a higher dose of radiation is more effective for treatment, but the higher the dose, the more danger it poses to healthy cells. Researchers at Yale have made significant inroads into solving this problem in a paper titled, “LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to […]
Prof. Euisik Yoon’s research group has developed a new, faster method to identify cancer stem-like cells (CSCs), which could help improve the effectiveness of cancer treatments. CSCs can seed and develop tumors in metastatic sites, causing cancer to relapse in patients after treatment. They are also generally resistant to chemotherapy and radiotherapy, so therapeutics that […]
A study by Vanderbilt researchers has identified genomic alterations in early stage adenocarcinomas of the lung that may indicate whether the lesions develop into aggressive tumors. The study published in the American Journal of Respiratory and Critical Care Medicine is the largest analysis of in situ and early adenocarcinomas lesions using targeted sequencing. Pierre Massion, […]