As reported in Nature Communications, researchers from Cleveland Clinic’s Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression.Ulcerative colitis is […]
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Microbiome profiling reveals associations with ulcerative colitis severity, treatment
A study of gut microbes from more than 400 children points to how the microbiome behaves in this inflammatory bowel disease. The gastrointestinal tract hosts a complicated set of relationships involving a variety of host cells (e.g., epithelial cells, immune cells) and the array of microbes that make their home inside the gut (collectively known […]